Zhao Yongna, Wang Zhichao, Ji Ruijun, Wang Yongjun, Zhang Yaguang, Yu Kai
Department of Neurology, Renqiu Kangji Hospital, Renqiu, China.
Department of Neurology, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, China.
Front Neurol. 2024 Jun 26;15:1383771. doi: 10.3389/fneur.2024.1383771. eCollection 2024.
This study aimed to examine the relationship between lipoprotein (a) (Lp[a]) and other blood lipid indexes and carotid artery atherosclerosis in patients with acute ischemic stroke (AIS).
A total of 2,018 patients were selected from the hospital "acute stroke intervention and secondary prevention registration database" by identifying blood fat indexes (cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and Lp[a]). Based on the results of carotid artery ultrasound examinations, the patients were divided into a "no plaque" group, comprising 400 patients, a "plaque and no stenosis" group, comprising 1,122 patients and a "carotid stenosis" group, comprising 496 patients. The relationship between Lp(a) and blood lipid indexes and carotid artery atherosclerosis was then investigated using multi-factor logistics regression analysis.
There were 400 patients (19.8%) with no carotid plaque, 1,122 patients (55.6%) with plaque and no carotid stenosis and 496 patients (24.6%) with carotid stenosis. As the degree of carotid artery atherosclerosis increased, the Lp(a) level gradually increased; Lp(a) and cholesterol were identified as independent risk factors for carotid atherosclerosis.
Lipoprotein (a) and cholesterol are independent risk factors for patients with AIS with carotid atherosclerosis, and their levels increase with the degree of carotid artery atherosclerosis; therefore, attention should focus on levels of cholesterol and Lp(a) in acute stroke patients to control atherosclerosis effectively.
本研究旨在探讨急性缺血性卒中（AIS）患者脂蛋白（a）[Lp（a）]与其他血脂指标及颈动脉粥样硬化之间的关系。
从医院“急性卒中干预与二级预防登记数据库”中选取2018例患者，检测其血脂指标（胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和Lp（a））。根据颈动脉超声检查结果，将患者分为“无斑块”组（400例）、“有斑块但无狭窄”组（1122例）和“颈动脉狭窄”组（496例）。然后采用多因素logistic回归分析研究Lp（a）与血脂指标及颈动脉粥样硬化之间的关系。
400例患者（19.8%）无颈动脉斑块，1122例患者（55.6%）有斑块但无颈动脉狭窄，496例患者（24.6%）有颈动脉狭窄。随着颈动脉粥样硬化程度的增加，Lp（a）水平逐渐升高；Lp（a）和胆固醇被确定为颈动脉粥样硬化的独立危险因素。
脂蛋白（a）和胆固醇是AIS合并颈动脉粥样硬化患者的独立危险因素，且其水平随颈动脉粥样硬化程度的增加而升高；因此，应关注急性卒中患者的胆固醇和Lp（a）水平，以有效控制动脉粥样硬化。
