Bulmer J N, Duckett A C
Anaesthesia. 1985 Aug;40(8):808-9. doi: 10.1111/j.1365-2044.1985.tb11012.x.
Seventeen patients undergoing split-skin grafting each received 3 mg/kg of a sterile 1% lignocaine gel applied to an area of the donor site equal to 3 sq cm/kg. Serial venous blood samples were taken for one hour following application and analysed for serum lignocaine concentration by high pressure liquid chromatography. The concentrations in all the patients were well below those associated with systemic toxicity. Clinical assessment included haemodynamic monitoring during the procedure, and postoperative evaluation of possible central nervous effects and of the degree of donor site analgesia obtained. No untoward effects were noted and the degree of analgesia, although difficult to assess, appeared good.
17名接受植皮手术的患者，每人在等于3平方厘米/千克体表面积的供皮区涂抹3毫克/千克的无菌1%利多卡因凝胶。涂抹后一小时内，每隔一段时间采集静脉血样，通过高压液相色谱法分析血清利多卡因浓度。所有患者的浓度均远低于与全身毒性相关的浓度。临床评估包括手术过程中的血流动力学监测，以及术后对可能的中枢神经效应和供皮区镇痛程度的评估。未观察到不良影响，尽管镇痛程度难以评估，但看起来效果良好。
