Gyawali Siddinath, Tiwari Sagar, Sah Guru Sharan, Panthi Bishal, Upreti Apil, Pokhrel Biraj, Gyawali Bindu, Khanal Pratima, Shrestha Rakshya, Paudel Bishal
Department of Internal Medicine, Tribhuvan University Teaching Hospital.
Central Hospital.
Ann Med Surg (Lond). 2024 May 28;86(7):3954-3958. doi: 10.1097/MS9.0000000000002232. eCollection 2024 Jul.
Patients with advanced cancer are more susceptible to develop sleep disorders like insomnia, restlessness, hypersomnolence, and sleep apnea due to a series of stressful events and side effects of chemotherapeutic agents. Poor sleep quality is associated with bad cancer outcomes and substandard quality of life. The authors assessed the prevalence of sleep disorders among advanced cancer patients in a tertiary center in Nepal.
Patients with stage three and four solid malignancies were enrolled from February 2023 to July 2023 to assess their sleep status. The data were collected using the Pittsburgh Sleep Quality Index (PSQI) questionnaire, analyzed using the Statistical Package for the Social Sciences (SPSS) version 27, and subgroup exploration was done to assess the relationship of poor sleep quality with gender, marital status, malignancy type, and treatment received. An ethical clearance was obtained from the Institutional Review Committee (IRC).
The authors evaluated data from 357 patients in the study. Of them, 58.3% were female and 41.7% were male. The mean age of the patients was 51.1 years. Among total cancer patients, 56% had significant sleep disorders. A significant association was observed between the quality of sleep and gender, type of malignancy, and treatment methods ( value <0.05). A majority of the patients demonstrated increased sleep latency, struggling to fall asleep swiftly.
More than half of the patients had poor sleep, which has an adverse impact on the prognosis of the disease and quality of life of cancer patients. Therefore, this aspect of cancer management requires special consideration for better quality of life and appropriate end-of-life care.
晚期癌症患者由于一系列应激事件和化疗药物的副作用，更容易出现失眠、烦躁、嗜睡和睡眠呼吸暂停等睡眠障碍。睡眠质量差与不良的癌症预后和生活质量低下相关。作者评估了尼泊尔一家三级中心晚期癌症患者睡眠障碍的患病率。
2023年2月至2023年7月招募了三、四期实体恶性肿瘤患者，以评估他们的睡眠状况。使用匹兹堡睡眠质量指数（PSQI）问卷收集数据，使用社会科学统计软件包（SPSS）27版进行分析，并进行亚组探索以评估睡眠质量差与性别、婚姻状况、恶性肿瘤类型和接受的治疗之间的关系。获得了机构审查委员会（IRC）的伦理批准。
作者评估了研究中357名患者的数据。其中，58.3%为女性，41.7%为男性。患者的平均年龄为51.1岁。在所有癌症患者中，56%有明显的睡眠障碍。观察到睡眠质量与性别、恶性肿瘤类型和治疗方法之间存在显著关联（ 值<0.05）。大多数患者表现出睡眠潜伏期延长，难以迅速入睡。
超过一半的患者睡眠质量差，这对疾病预后和癌症患者的生活质量产生不利影响。因此，癌症管理的这一方面需要特别考虑，以提高生活质量和提供适当的临终关怀。
