Chemistry and Bioprospecting Division, ICFRE-Forest Research Institute, Dehradun, 248006, India.
J Mass Spectrom. 2024 Aug;59(8):e5075. doi: 10.1002/jms.5075.
Prinsepia utilis Royle, native to the Himalayas, is esteemed in Chinese and Indian folk medicine for its diverse medicinal benefits, targeting arthritis, pain relief, bone disorders, and joint discomfort. This study examined the 25% aqueous methanol extract of P. utilis leaves using UPLC-Q-TOF-MS/MS, identifying 78 metabolites, 76 of which were reported for the first time in P. utilis. These included 64 phenolics represented by 56 flavonoids, 5 phenolic acids, 3 phenolic glycosides, 4 terpenoids, 2 lignan glycosides, and 8 other compounds, expanding the knowledge of its chemical composition. These findings lay a foundation for further research, providing insights into potential bioactive compounds and opening avenues for applications in natural product drug discovery, traditional medicine, and nutraceutical development, leveraging the plant's established traditional uses.
圆叶玉兰（Prinsepia utilis Royle）原产于喜马拉雅山脉，在中国和印度民间医学中备受推崇，因其具有多种药用功效而备受重视，可用于治疗关节炎、缓解疼痛、骨骼疾病和关节不适。本研究采用 UPLC-Q-TOF-MS/MS 分析了圆叶玉兰叶的 25%甲醇水提取物，共鉴定出 78 种代谢产物，其中 76 种在圆叶玉兰中为首次报道。这些代谢产物包括 64 种酚类化合物，其中 56 种为黄酮类化合物，5 种为酚酸类化合物，3 种为酚苷类化合物，4 种为萜类化合物，2 种为木脂素苷类化合物，以及 8 种其他化合物，这些发现扩展了人们对其化学成分的认识。这些研究结果为进一步研究奠定了基础，为潜在的生物活性化合物提供了新的见解，并为天然产物药物发现、传统医学和营养保健品开发等领域的应用开辟了新的途径，充分利用了该植物已确立的传统用途。
