Carrera-Bastos Pedro, Fontes-Villalba Maelán, Ahrén Bo, Lindblad Ulf, Råstam Lennart, Frostegård Johan, Åkerfeldt Torbjörn, Granfeldt Yvonne, Sundquist Kristina, Jönsson Tommy
Center for Primary Health Care Research, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Department of Clinical Sciences, Lund, Lund University, Lund, Sweden.
Am J Hum Biol. 2024 Oct;36(10):e24134. doi: 10.1002/ajhb.24134. Epub 2024 Jul 11.
Experimental and small human studies have indicated that high total adiponectin levels have beneficial cardiometabolic effects. In contrast, however, high total adiponectin levels are also associated with higher all-cause and cardiovascular mortality in thoroughly adjusted epidemiological studies. To gain further insight into these seemingly contradictory results, we report results on total adiponectin from the indigenous Melanesian population of Kitava, Trobriand Islands, Papua New Guinea, where an apparent absence of cardiometabolic disease has been previously reported.
Fasting levels of serum total adiponectin were measured cross-sectionally in ≥40-year-old Kitavans (n = 102) and Swedish controls matched for age and sex (n = 108). Multivariable linear regression was used for the analysis of associations with total adiponectin when controlled for group, sex, smoking, hypertension and/or type 2 diabetes, age, and body mass index.
Total adiponectin was lower for Kitavans compared to Swedish controls (Median [Mdn] 4.6 μg/mL, range 1.0-206 μg/mL and Mdn 9.7 μg/mL, range 3.1-104 μg/mL, respectively, r = .64, p < .001). Lower total adiponectin was associated with Kitavan group, male sex (only in Swedish controls), smoking (only in Kitavans and Swedish controls combined), younger age (not in Swedish controls), higher BMI, lower total, low-density lipoprotein, high-density lipoprotein (HDL) (only in Kitavans and Swedish controls combined), and non-HDL cholesterol, and higher anti-PC IgG (only in Kitavans and Swedish controls combined).
Total adiponectin in Kitavans was significantly lower than in Swedish controls.
实验研究和小型人体研究表明，较高的总脂联素水平具有有益的心脏代谢效应。然而，相比之下，在经过充分调整的流行病学研究中，较高的总脂联素水平也与全因死亡率和心血管死亡率升高有关。为了进一步了解这些看似矛盾的结果，我们报告了来自巴布亚新几内亚特罗布里恩群岛基塔瓦岛的美拉尼西亚原住民的总脂联素研究结果，此前有报道称该地区明显不存在心脏代谢疾病。
对年龄≥40岁的基塔瓦岛居民（n = 102）和年龄及性别匹配的瑞典对照组（n = 108）进行空腹血清总脂联素水平的横断面测量。在控制了组别、性别、吸烟、高血压和/或2型糖尿病、年龄和体重指数后，采用多变量线性回归分析与总脂联素的关联。
与瑞典对照组相比，基塔瓦岛居民的总脂联素水平较低（中位数[Mdn]分别为4.6μg/mL，范围1.0 - 206μg/mL和Mdn 9.7μg/mL，范围3.1 - 104μg/mL，r = 0.64，p < 0.001）。较低的总脂联素水平与基塔瓦岛居民组、男性（仅在瑞典对照组中）、吸烟（仅在基塔瓦岛居民和瑞典对照组合并分析中）、较年轻的年龄（在瑞典对照组中不显著）、较高的体重指数、较低的总胆固醇、低密度脂蛋白、高密度脂蛋白（HDL）（仅在基塔瓦岛居民和瑞典对照组合并分析中）和非HDL胆固醇，以及较高的抗PC IgG（仅在基塔瓦岛居民和瑞典对照组合并分析中）相关。
基塔瓦岛居民的总脂联素水平显著低于瑞典对照组。
