基于壳聚糖的交联用于鼻窦炎中局部药物的控释
Chitosan-based crosslinking for controlled topical drug release in rhinosinusitis.
作者信息
Cho Do-Yeon, Lim Dong Jin, Kelly Olivia J, Skinner Daniel, Zhang Shaoyan, Jones Martin P, Grayson Jessica, Woodworth Bradford A
机构信息
Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
出版信息
Int Forum Allergy Rhinol. 2024 Nov;14(11):1802-1805. doi: 10.1002/alr.23413. Epub 2024 Jul 11.
Abstract
Chitosan is a promising drug delivery vector for therapeutics owing to its biocompatibility. Once crosslinked with chitosan, prolonged drug release was noted regardless of hydrophilicity. Hydrophilic drugs may require different strategies to obtain a sustained release profile.
摘要
由于壳聚糖具有生物相容性，它是一种很有前景的治疗药物递送载体。一旦与壳聚糖交联，无论亲水性如何，都能实现药物的长效释放。亲水性药物可能需要不同的策略来获得缓释特性。
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