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本文引用的文献

1
Use of Off-Label Nasal Steroid Irrigations in Long-Term Management of Chronic Rhinosinusitis.在慢性鼻-鼻窦炎的长期管理中使用非标签鼻腔类固醇冲洗。
Ear Nose Throat J. 2021 Jun;100(5):329-334. doi: 10.1177/0145561321998521. Epub 2021 Mar 8.
2
In-vitro evaluation of a ciprofloxacin and azithromycin sinus stent for Pseudomonas aeruginosa biofilms.体外评价左氧氟沙星和阿奇霉素鼻窦支架对铜绿假单胞菌生物膜的作用。
Int Forum Allergy Rhinol. 2020 Jan;10(1):121-127. doi: 10.1002/alr.22475. Epub 2019 Nov 6.
3
Topical therapies for management of chronic rhinosinusitis: steroid implants.慢性鼻-鼻窦炎的局部治疗：皮质类固醇植入物。
Int Forum Allergy Rhinol. 2019 May;9(S1):S22-S26. doi: 10.1002/alr.22344.
4
In-vitro evaluation of a ciprofloxacin- and ivacaftor-coated sinus stent against Pseudomonas aeruginosa biofilms.体外评估环丙沙星和 ivacaftor 涂层鼻窦支架对抗铜绿假单胞菌生物膜的效果。
Int Forum Allergy Rhinol. 2019 May;9(5):486-492. doi: 10.1002/alr.22285. Epub 2019 Jan 31.
5
Chitosan-Based Nanomaterials for Drug Delivery.基于壳聚糖的药物递送纳米材料。
Molecules. 2018 Oct 16;23(10):2661. doi: 10.3390/molecules23102661.
6
Infectious Chronic Rhinosinusitis.感染性慢性鼻-鼻窦炎
J Allergy Clin Immunol Pract. 2016 Jul-Aug;4(4):584-9. doi: 10.1016/j.jaip.2016.04.008.
7
Optimization of levofloxacin-loaded crosslinked chitosan microspheres for inhaled aerosol therapy.用于吸入气雾剂治疗的载左氧氟沙星交联壳聚糖微球的优化
Eur J Pharm Biopharm. 2015 Oct;96:65-75. doi: 10.1016/j.ejpb.2015.07.010. Epub 2015 Jul 17.
8
Use of topical nasal therapies in the management of chronic rhinosinusitis.局部鼻腔治疗在慢性鼻-鼻窦炎治疗中的应用。
Laryngoscope. 2013 Oct;123(10):2347-59. doi: 10.1002/lary.24066. Epub 2013 Apr 1.
9
Chronic rhinosinusitis as a multifactorial inflammatory disorder.慢性鼻-鼻窦炎是一种多因素炎症性疾病。
Curr Infect Dis Rep. 2011 Apr;13(2):159-68. doi: 10.1007/s11908-011-0166-z.

基于壳聚糖的交联用于鼻窦炎中局部药物的控释

Chitosan-based crosslinking for controlled topical drug release in rhinosinusitis.

作者信息

Cho Do-Yeon, Lim Dong Jin, Kelly Olivia J, Skinner Daniel, Zhang Shaoyan, Jones Martin P, Grayson Jessica, Woodworth Bradford A

机构信息

Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.

出版信息

Int Forum Allergy Rhinol. 2024 Nov;14(11):1802-1805. doi: 10.1002/alr.23413. Epub 2024 Jul 11.

DOI:10.1002/alr.23413
PMID:38990106
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11530306/
Abstract

Chitosan is a promising drug delivery vector for therapeutics owing to its biocompatibility. Once crosslinked with chitosan, prolonged drug release was noted regardless of hydrophilicity. Hydrophilic drugs may require different strategies to obtain a sustained release profile.

摘要

由于壳聚糖具有生物相容性，它是一种很有前景的治疗药物递送载体。一旦与壳聚糖交联，无论亲水性如何，都能实现药物的长效释放。亲水性药物可能需要不同的策略来获得缓释特性。