Department of Urology, Taipei Medical University Hospital, No. 252, Wu-Xing Street, Taipei, 11031, Taiwan.
School of Medicine, Department of Urology, Taipei Medical University, Taipei, Taiwan.
World J Urol. 2024 Jul 11;42(1):405. doi: 10.1007/s00345-024-05100-3.
To investigate the protective effect of intravesical glucosamine in treating overactive bladder (OAB).
Ninety-two female Sprague-Dawley (SD) rats were divided into 4 groups i.e. protamine sulfate (PS), N-acetylcysteine (NAC), and glucosamine-treated PS (GPS), and normal saline control (NC) were used. We induced hyperactivity in rats via intravesical infusion of PS and potassium chloride (KCl), whereas the NC group underwent a sustained intravesical saline infusion for 1 h. N-acetylcysteine (NAC), a potential antioxidant as well as anti-inflammatory agent was employed as positive control. Cystometrography (CMG) was then conducted to determine urodynamic parameters, i.e., leak point pressure (LPP, n = 48) and inter-contractile interval, the duration between two voids (ICI, n = 32).
LPP was significantly elevated in the GPS group (mean ± SD: 110.9 ± 6.2 mmHg) compared to the NC (81.0 ± 32.5 mmHg), PS (40.3 ± 10.9 mmHg), and NAC group (70.3 ± 19.4 mmHg). The cystometrogram data also reveals a prolonged ICI in the GPS group (241.3 ± 40.2 s) compared to the NC group (216.0 ± 41.7 s), PS group (128.8 ± 23.6 s), and NAC group (193.8 ± 28.3 s).
This preliminary study implies the ameliorative impact of GPS treatment on OAB in terms of improved urodynamic parameters, including LPP and ICI.
研究膀胱内葡糖胺对治疗膀胱过度活动症（OAB）的保护作用。
92 只雌性 SD 大鼠随机分为硫酸鱼精蛋白（PS）组、N-乙酰半胱氨酸（NAC）组、葡糖胺处理 PS（GPS）组和生理盐水对照组（NC），每组 23 只。通过膀胱内灌注 PS 和氯化钾（KCl）诱导大鼠膀胱过度活动，NC 组持续膀胱内灌注生理盐水 1 h。N-乙酰半胱氨酸（NAC）作为一种潜在的抗氧化剂和抗炎剂被用作阳性对照。然后进行尿动力学检测，确定压力漏点（LPP，n=48）和两次排尿间隔（ICI，n=32）的收缩间期。
与 NC 组（81.0±32.5 mmHg）、PS 组（40.3±10.9 mmHg）和 NAC 组（70.3±19.4 mmHg）相比，GPS 组的 LPP 显著升高（均值±标准差：110.9±6.2 mmHg）。GPS 组的 ICI 也显著延长（241.3±40.2 s），与 NC 组（216.0±41.7 s）、PS 组（128.8±23.6 s）和 NAC 组（193.8±28.3 s）相比。
本初步研究表明，GPS 治疗可改善压力漏点和 ICI 等尿动力学参数，从而改善 OAB。
