Kääpä P, Knip M, Viinikka L, Ylikorkala O
Biol Neonate. 1985;48(2):65-9. doi: 10.1159/000242155.
Plasma concentrations of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), C-peptide and pancreatic glucagon and blood glucose levels were measured in 13 infants of insulin-dependent diabetic mothers at the age of 2 h. Plasma 6-keto-PGF1 alpha levels were lower in these infants when compared to those of healthy controls at the same age (p less than 0.05). Plasma 6-keto-PGF1 alpha correlated negatively with the C-peptide levels (r = -0.57; p less than 0.05) and positively with the pancreatic glucagon concentrations (r = 0.83; p less than 0.001) in the infants of diabetic mothers. No correlation with blood glucose concentrations was found. The data suggest that hyperinsulinemia in infants of diabetic mothers is associated with a decreased vascular prostacyclin production.
对13名胰岛素依赖型糖尿病母亲的婴儿在出生2小时时测定了血浆6-酮-前列腺素F1α（6-keto-PGF1α）、C肽、胰高血糖素水平及血糖水平。与同年龄健康对照组相比，这些婴儿的血浆6-酮-前列腺素F1α水平较低（p<0.05）。糖尿病母亲的婴儿血浆6-酮-前列腺素F1α水平与C肽水平呈负相关（r=-0.57；p<0.05），与胰高血糖素浓度呈正相关（r=0.83；p<0.001）。未发现与血糖浓度相关。数据表明，糖尿病母亲的婴儿高胰岛素血症与血管前列环素生成减少有关。
