Stuart M J, Sunderji S G, Walenga R W, Setty B N
Br Med J (Clin Res Ed). 1985 Jun 8;290(6483):1700-2. doi: 10.1136/bmj.290.6483.1700.
The infant of the diabetic mother has an increased incidence of thromboses in utero and in the neonatal period. In the adult with diabetes a decrease in prostacyclin formation has been suggested as a cause for the atherothrombotic tendency. We therefore evaluated arachidonic acid metabolism in infants of diabetic mothers. Endogenous radioimmunoassayable 6-keto prostaglandin F1 alpha (PGF1 alpha) was normal in umbilical vessels obtained from the infants of diabetic mothers whose glucose homoeostasis was maintained when compared with control values. Nevertheless, a significant inhibition of vascular production of 6-keto PGF1 alpha was observed in infants born to mothers with raised HbA1C concentrations. A decrease in the concentration of plasma 6-keto PGF1 alpha was also seen in the infants of diabetic mothers when compared with control neonates. The correlation observed between plasma 6-keto PGF1 alpha concentrations and endogenous vascular prostacyclin formation in the infants of diabetic mothers indicates that the in vitro deficiency of prostacyclin formation reflects a concomitant in vivo abnormality.
糖尿病母亲的婴儿在子宫内和新生儿期发生血栓的几率增加。对于成年糖尿病患者，有人提出前列环素生成减少是动脉粥样血栓形成倾向的一个原因。因此，我们评估了糖尿病母亲婴儿的花生四烯酸代谢情况。与对照值相比，从血糖稳态得以维持的糖尿病母亲婴儿的脐血管中，内源性可通过放射免疫法检测的6-酮前列腺素F1α（PGF1α）正常。然而，在母亲HbA1C浓度升高的婴儿中，观察到血管生成6-酮PGF1α受到显著抑制。与对照新生儿相比，糖尿病母亲的婴儿血浆6-酮PGF1α浓度也有所降低。糖尿病母亲婴儿血浆6-酮PGF1α浓度与内源性血管前列环素生成之间的相关性表明，体外前列环素生成不足反映了体内同时存在的异常情况。
