通过血清素在胃肠道中的作用对帕金森病和抑郁症影响的新见解。
New insights into the effects of serotonin on Parkinson's disease and depression through its role in the gastrointestinal tract.
作者信息
Sancho-Alonso María, Sarriés-Serrano Unai, Miquel-Rio Lluis, Yanes Castilla Claudia, Paz Verónica, Meana José Javier, Perello Mario, Bortolozzi Analia
机构信息
Institute of Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), 08036 Barcelona, Spain; Systems Neuropharmacology Research Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain; Biomedical Research Networking Center for Mental Health (CIBERSAM), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain; Anatomy and Human Embryology Department, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain.
Institute of Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), 08036 Barcelona, Spain; Systems Neuropharmacology Research Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain; Biomedical Research Networking Center for Mental Health (CIBERSAM), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain; University of the Basque Country UPV/EHU, E-48940 Leioa, Bizkaia, Spain.
出版信息
Span J Psychiatry Ment Health. 2024 Jul 9. doi: 10.1016/j.sjpmh.2024.07.002.
Neuropsychiatric and neurodegenerative disorders are frequently associated with gastrointestinal (GI) co-pathologies. Although the central and enteric nervous systems (CNS and ENS, respectively) have been studied separately, there is increasing interest in factors that may contribute to conditions affecting both systems. There is compelling evidence that serotonin (5-HT) may play an important role in several gut-brain disorders. It is well known that 5-HT is essential for the development and functioning of the CNS. However, most of the body's 5-HT is produced in the GI tract. A deeper understanding of the specific effects of enteric 5-HT on gut-brain disorders may provide the basis for the development of new therapeutic targets. This review summarizes current data focusing on the important role of 5-HT in ENS development and motility, with particular emphasis on novel aspects of 5-HT signaling in conditions where CNS and ENS comorbidities are common, such as Parkinson's disease and depressive disorders.
神经精神疾病和神经退行性疾病常与胃肠道（GI）共病相关。尽管中枢神经系统和肠神经系统（分别为CNS和ENS）已被分别研究，但人们对可能导致影响这两个系统的病症的因素越来越感兴趣。有令人信服的证据表明，血清素（5-羟色胺，5-HT）可能在几种肠-脑疾病中起重要作用。众所周知，5-HT对CNS的发育和功能至关重要。然而，人体大部分的5-HT是在胃肠道中产生的。对肠5-HT对肠-脑疾病的具体影响有更深入的了解，可能为开发新的治疗靶点提供基础。本综述总结了当前的数据，重点关注5-HT在ENS发育和运动中的重要作用，特别强调在CNS和ENS共病常见的情况下，如帕金森病和抑郁症中，5-HT信号传导的新方面。
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