Ganz Marc, Miller Daniel, Appiah Jude, Sezanayev David, Kohanbash Emily, Khanimov David, Winer Andrew
Department of Urology, State University of New York Downstate Health Sciences University, Brooklyn, USA.
Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, USA.
Cureus. 2024 Jun 11;16(6):e62188. doi: 10.7759/cureus.62188. eCollection 2024 Jun.
Introduction Heart failure (HF) represents a substantial global health concern, evidenced by its high prevalence, significant mortality rates, and considerable economic impact worldwide. Within this broader context, congestive heart failure (CHF) emerges as a critical subset, affecting millions and leading to high rates of morbidity and mortality. Recent explorations have started to uncover a potential link between kidney stones and broader systemic health problems, including coronary artery disease. This association suggests that kidney stones might also indicate an increased risk for cardiovascular diseases such as CHF. However, the exploration into the direct relationship between kidney stones and CHF is still in its nascent stages, creating a significant gap in understanding the full cardiovascular implications of kidney stone disease. Methods Utilizing data from the National Health and Nutrition Examination Survey (NHANES) for the period of March 2017 to March 2020, we conducted a logistic regression analysis to assess the relationship between kidney stones and CHF. This analysis adjusted for key variables such as age, gender, race, and educational attainment, aiming to isolate the impact of kidney stones on CHF risk among 8,521 participants. Results Our findings revealed a higher incidence of CHF among individuals with a history of kidney stones (7%) compared to those without (3%). Logistic regression analysis further highlighted kidney stones as an independent risk factor for CHF, with an odds ratio (OR) of 1.857, significant at p < 0.01. These results underline the importance of considering kidney stones in the broader context of cardiovascular health risks, particularly CHF, as their presence significantly elevates the risk compared to the general population without kidney stones. Additional demographic analyses indicated significant influences of age, gender, race, and educational level on the risk of CHF, emphasizing the complex interplay between these factors and heart health. Conclusion The study confirms the association between a history of kidney stones and an increased risk of CHF, suggesting the need for heightened cardiovascular monitoring for patients with such a history. It also brings to light the significant role demographic factors play in CHF risk, advocating for targeted interventions to mitigate these disparities. Our research supports a broader view of patient care that includes consideration of urological conditions as potential risk factors for heart failure. Further exploration into the mechanisms linking kidney stones and cardiovascular health is recommended to inform more effective prevention and treatment strategies.
引言
心力衰竭(HF)是一个重大的全球健康问题,其高患病率、高死亡率以及在全球范围内产生的巨大经济影响都证明了这一点。在这一广泛背景下,充血性心力衰竭(CHF)成为一个关键的子集,影响着数百万人,并导致高发病率和死亡率。最近的研究开始揭示肾结石与更广泛的全身健康问题之间的潜在联系,包括冠状动脉疾病。这种关联表明,肾结石也可能预示着患心血管疾病如CHF的风险增加。然而,对肾结石与CHF之间直接关系的探索仍处于初期阶段,在理解肾结石疾病对心血管系统的全面影响方面存在重大差距。
方法
利用2017年3月至2020年3月期间美国国家健康与营养检查调查(NHANES)的数据,我们进行了逻辑回归分析,以评估肾结石与CHF之间的关系。该分析对年龄、性别、种族和教育程度等关键变量进行了调整,旨在在8521名参与者中分离出肾结石对CHF风险的影响。
结果
我们的研究结果显示,有肾结石病史的个体中CHF的发病率(7%)高于无肾结石病史的个体(3%)。逻辑回归分析进一步强调肾结石是CHF的独立危险因素,优势比(OR)为1.857,在p < 0.01时具有显著性。这些结果强调了在更广泛的心血管健康风险背景下,尤其是CHF方面,考虑肾结石的重要性,因为与没有肾结石的普通人群相比,肾结石的存在显著增加了风险。额外的人口统计学分析表明,年龄、性别、种族和教育水平对CHF风险有显著影响,强调了这些因素与心脏健康之间复杂的相互作用。
结论
该研究证实了肾结石病史与CHF风险增加之间的关联,表明需要对有此类病史的患者加强心血管监测。它还揭示了人口统计学因素在CHF风险中所起的重要作用,提倡采取有针对性的干预措施来减轻这些差异。我们的研究支持一种更广泛的患者护理观点,即把泌尿系统疾病视为心力衰竭的潜在危险因素。建议进一步探索肾结石与心血管健康之间的联系机制,以制定更有效的预防和治疗策略。