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评估鸦片对Wistar大鼠膀胱中[具体物质1]和[具体物质2]表达的影响。 （原文中“and”前后的具体物质未给出完整信息）

Evaluation of the Effects of Opium on the Expression of and in Wistar Rat Bladder.

作者信息

Menbari Oskouie Iman, Zareian Baghdadabad Leila, Mashhadi Rahil, Zahmatkesh Parisa, Mirzaei Akram, Khajavi Alireza, Noori Maryam, Mesbah Gholamreza, Aghamir Seyed Mohammad Kazem

机构信息

School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Bladder Cancer. 2024 Mar 12;10(1):47-59. doi: 10.3233/BLC-230076. eCollection 2024.

DOI:10.3233/BLC-230076
PMID:38993529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11181810/
Abstract

BACKGROUND

Bladder cancer is a malignancy greatly affected by behavioral habits. The aim of this study was to examine the effect of opium on changes in the expression of and in the bladder tissue of rats.

METHOD

Thirty six rats were divided into six groups: 24 rats in the addicted group received morphine and opium for 4 months with 12 rats in the control group. Blood testing was done for the evaluation of CBC, MDA, and TAC. The bladder tissue was removed and checked by histopathological examination. All total RNA was extracted, then cDNAs were synthesized and the OCT and gene expressions were evaluated by Real-time PCR.

RESULTS

The mRNA expression level in the opium group of rats was significantly increased compared to the control group (13.5 and 6.8 fold in males and females respectively). Also, in the morphine group, similar augmentation was detected (3.8 and 6.7 fold in males and females respectively). The mRNA over-expression level was seen in the morphine group of both genders as compared to the control group (3.7 and 4.2 fold in male and female respectively) but in the opium group, enhancement of mRNA level was seen only in males (6.6 fold). Opium increases both and expression more than morphine in male rats, but in female rats, is increased more by morphine.

CONCLUSION

Over expression of and was observed in rats treated with opium and morphine. Increased and expression was seen in opium-treated male rats, but in female rats, was increased more by morphine.

摘要

背景

膀胱癌是一种受行为习惯影响很大的恶性肿瘤。本研究的目的是检测鸦片对大鼠膀胱组织中[具体基因名称1]和[具体基因名称2]表达变化的影响。

方法

将36只大鼠分为六组：成瘾组的24只大鼠接受吗啡和鸦片处理4个月，对照组有12只大鼠。进行血液检测以评估全血细胞计数、丙二醛和总抗氧化能力。取出膀胱组织并通过组织病理学检查进行检查。提取所有总RNA，然后合成cDNA，并通过实时聚合酶链反应评估[具体基因名称1]和[具体基因名称2]的基因表达。

结果

与对照组相比，鸦片组大鼠的[具体基因名称1]信使核糖核酸表达水平显著升高（雄性和雌性分别为13.5倍和6.8倍）。此外，在吗啡组中也检测到类似的增加（雄性和雌性分别为3.8倍和6.7倍）。与对照组相比，吗啡组两性的[具体基因名称2]信使核糖核酸过表达水平均可见（雄性和雌性分别为3.7倍和4.2倍），但在鸦片组中，信使核糖核酸水平仅在雄性中增强（6.6倍）。在雄性大鼠中，鸦片比吗啡更能增加[具体基因名称1]和[具体基因名称2]的表达，但在雌性大鼠中，吗啡对[具体基因名称2]的增加作用更大。

结论

在接受鸦片和吗啡处理的大鼠中观察到[具体基因名称1]和[具体基因名称2]的过表达。在接受鸦片处理的雄性大鼠中可见[具体基因名称1]和[具体基因名称2]表达增加，但在雌性大鼠中，吗啡对[具体基因名称2]的增加作用更大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/27afc0f5573e/blc-10-blc230076-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/b5b4a15012f2/blc-10-blc230076-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/92b38c97791f/blc-10-blc230076-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/e140cc23708d/blc-10-blc230076-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/da2c5e802f4a/blc-10-blc230076-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/66a301628be5/blc-10-blc230076-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/bf8213738285/blc-10-blc230076-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/27afc0f5573e/blc-10-blc230076-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/b5b4a15012f2/blc-10-blc230076-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/92b38c97791f/blc-10-blc230076-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/e140cc23708d/blc-10-blc230076-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/da2c5e802f4a/blc-10-blc230076-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/66a301628be5/blc-10-blc230076-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/bf8213738285/blc-10-blc230076-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f593/11181810/27afc0f5573e/blc-10-blc230076-g007.jpg

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Int J Epidemiol. 2022 Jun 13;51(3):830-838. doi: 10.1093/ije/dyac031.
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Substance of choice, impact of heroin or opium on treatment retention in a multicentre randomised controlled trial in Iran.在伊朗进行的一项多中心随机对照试验中，首选药物、海洛因或鸦片对治疗依从性的影响。
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Opium use as an independent risk factor for pancreatic cancer: A case-control study.
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Opium use and the risk of head and neck squamous cell carcinoma.鸦片使用与头颈部鳞状细胞癌风险
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