Nishimura Yusuke
Department of Clinical Engineering, Faculty of Medical Science and Technology, Gunma Paz University, 3-3-4 Tonyamachi, Takasaki-shi, Gunma, 370-0006, Japan.
Regen Ther. 2024 Jun 17;26:275-280. doi: 10.1016/j.reth.2024.06.006. eCollection 2024 Jun.
In vitro models of kidneys have limited effectiveness owing to the complex structure and functions of the kidney when compared with other organs. Therefore many renal function evaluations are currently being carried out through animal experiments. In contrast, efforts are being made to apply biomimetic systems, such as organ-on-a-chip, which is based on microfluidic device technology, to serve as an in vitro model for the kidney. These systems aimed to recreate a physiological cultivation environment. This review has provided an overview of organ-on-a-chip research focused on glomeruli and tubules as in vitro models for the kidney and discusses future prospects.
与其他器官相比，由于肾脏结构和功能复杂，肾脏的体外模型有效性有限。因此，目前许多肾功能评估是通过动物实验进行的。相比之下，人们正在努力应用基于微流控设备技术的仿生系统，如芯片器官，作为肾脏的体外模型。这些系统旨在重现生理培养环境。本文综述了以肾小球和肾小管为肾脏体外模型的芯片器官研究概况，并探讨了未来前景。
