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推进血管化复合组织异体移植:上肢移植项目发展的关键因素。

Advancing vascularized composite allotransplantation: essential factors for upper extremity transplant program development.

作者信息

Kumnig Martin, Kobler Caroline, Zaccardelli Alessandra, Brandacher Gerald, Talbot Simon G

机构信息

Department of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, Center for Advanced Psychology in Plastic and Transplant Surgery, Medical University of Innsbruck, Innsbruck, Austria.

Division of Plastic Surgery, Brigham and Women's Hospital, Boston, MA, United States.

出版信息

Front Transplant. 2024 Jun 11;3:1406626. doi: 10.3389/frtra.2024.1406626. eCollection 2024.

DOI:10.3389/frtra.2024.1406626
PMID:38993746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11235377/
Abstract

Vascularized Composite Allotransplantation (VCA) offers a unique option to restore form and function after limb loss or facial trauma that cannot be satisfactorily accomplished through traditional prosthetics or reconstructions. Establishing a successful Upper Extremity Transplantation (UET) program requires strong leadership and a structured surgical team, and extensive interdisciplinary collaboration. We conducted a qualitative study among 12 health care professionals and patients. Informed consent was obtained per protocol, and semi-structured interviews were conducted online and recorded. Participants reported their perceptions of factors that either favored or hindered a successful outcome, including functional status before and after surgery, preparation for transplant, shared decision-making, rehabilitation, and psychosocial support. Thematic analysis revealed that it is essential to establish a team comprising various disciplines well before performing VCA procedures. Defining a common goal and choosing a defined leader is a key factor in procedural success and requires open collaboration beyond what is typical. Primary described categories are interdisciplinary collaboration and skills of the VCA team, building and leading a VCA team, pre-transplant procedures, post-transplant course, and factors to consider when establishing a program. The basic roles of team science play an outsized role in establishing a VCA program. Transplantation medicine involves various overlapping scientific and medical categories requiring health professionals to consciously work together to establish complex vertical and horizontal communication webs between teams to obtain positive outcomes. In addition to medical considerations, patient-specific factors such as transparent communication, therapy plan establishment, plan adherence, and continual follow-up are significant factors to overall success.

摘要

血管化复合组织异体移植(VCA)为肢体缺失或面部创伤后恢复外形和功能提供了一种独特的选择,而这是传统假肢或重建手术无法令人满意地实现的。建立一个成功的上肢移植(UET)项目需要强有力的领导、结构化的手术团队以及广泛的跨学科协作。我们对12名医疗保健专业人员和患者进行了一项定性研究。按照方案获得了知情同意,并通过在线方式进行了半结构化访谈并录音。参与者报告了他们对有利于或阻碍成功结果的因素的看法,包括手术前后的功能状态、移植准备、共同决策、康复以及心理社会支持。主题分析表明,在进行VCA手术之前很久就组建一个由各学科组成的团队至关重要。确定一个共同目标并选择一位明确的领导者是手术成功的关键因素,这需要超越常规的开放协作。主要描述的类别包括跨学科协作和VCA团队的技能、组建和领导VCA团队、移植前程序、移植后过程以及建立项目时需要考虑的因素。团队科学的基本作用在建立VCA项目中发挥着巨大作用。移植医学涉及各种重叠的科学和医学类别,要求卫生专业人员有意识地共同努力,在团队之间建立复杂的纵向和横向沟通网络,以取得积极成果。除了医学方面的考虑,患者特定因素,如透明沟通、治疗计划制定、计划依从性和持续随访,也是总体成功的重要因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f5/11235377/ea3cba490350/frtra-03-1406626-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f5/11235377/ea3cba490350/frtra-03-1406626-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27f5/11235377/ea3cba490350/frtra-03-1406626-g001.jpg

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Front Transplant. 2024 Jun 11;3:1406626. doi: 10.3389/frtra.2024.1406626. eCollection 2024.
2
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本文引用的文献

1
Vascularized Composite Allotransplantation of the Hand: A Systematic Review of Eligibility Criteria.手部血管化复合组织移植的适应证:系统评价。
Ann Plast Surg. 2023 Dec 1;91(6):771-778. doi: 10.1097/SAP.0000000000003659. Epub 2023 Aug 12.
2
Psychosocial Risk Stratification in Upper Extremity Transplantation Candidates.上肢移植候选者的心理社会风险分层
Hand (N Y). 2025 Jan;20(1):116-121. doi: 10.1177/15589447231184895. Epub 2023 Jul 6.
3
Patient preferences of patient selection criteria for upper extremity vascularized composite allotransplantation: A qualitative study.
上肢血管化复合组织异体移植患者选择标准的患者偏好:一项定性研究。
SAGE Open Med. 2023 Jun 15;11:20503121231181236. doi: 10.1177/20503121231181236. eCollection 2023.
4
Psychosocial predictors in upper-extremity vascularized composite allotransplantation: A qualitative study of multidimensional experiences including patients, healthcare professionals, and close relatives.上肢血管化复合组织异体移植中的社会心理预测因素:一项关于包括患者、医护人员和近亲在内的多维度体验的定性研究。
Front Psychol. 2023 Feb 9;14:1092725. doi: 10.3389/fpsyg.2023.1092725. eCollection 2023.
5
A Patient-Centered Website (Within Reach) to Foster Informed Decision-making About Upper Extremity Vascularized Composite Allotransplantation: Development and Usability Study.一个以患者为中心的网站(触手可及),以促进关于上肢血管化复合组织异体移植的明智决策:开发与可用性研究。
JMIR Form Res. 2023 Feb 7;7:e44144. doi: 10.2196/44144.
6
Social support criteria in vascularized composite allotransplantation versus solid organ transplantation: Should the same ethical considerations apply?血管化复合组织异体移植与实体器官移植中的社会支持标准:是否应适用相同的伦理考量?
Front Psychol. 2022 Nov 22;13:1055503. doi: 10.3389/fpsyg.2022.1055503. eCollection 2022.
7
Vascularized composite allotransplantation: emerging psychosocial issues in hand, face, and uterine transplant.血管化复合组织同种异体移植:手、面和子宫移植中的新兴心理社会问题。
Curr Opin Organ Transplant. 2022 Dec 1;27(6):501-507. doi: 10.1097/MOT.0000000000001028. Epub 2022 Oct 13.
8
Using team science in vascularized composite allotransplantation to improve team and patient outcomes.在血管化复合组织异体移植中运用团队科学以改善团队和患者的治疗效果。
Front Psychol. 2022 Sep 6;13:935507. doi: 10.3389/fpsyg.2022.935507. eCollection 2022.
9
Recipient Selection Criteria for Facial Transplantation: A Systematic Review.面部移植的受者选择标准:系统评价。
Ann Plast Surg. 2022 Jul 1;89(1):105-112. doi: 10.1097/SAP.0000000000003255.
10
Evaluation of an eLearning System to Train Health Professionals to Communicate about Vascularized Composite Allotransplantation with Donor Families.评价一个电子学习系统,以培训医疗专业人员与供者家属就血管化复合组织同种异体移植进行沟通。
Prog Transplant. 2022 Sep;32(3):233-240. doi: 10.1177/15269248221107040. Epub 2022 Jun 10.