调节性T细胞在移植耐受中的作用及治疗潜力。

Tregs in transplantation tolerance: role and therapeutic potential.

作者信息

Cassano Alexandra, Chong Anita S, Alegre Maria-Luisa

机构信息

Department of Medicine, University of Chicago, Chicago, IL, United States.

Department of Surgery, University of Chicago, Chicago, IL, United States.

出版信息

Front Transplant. 2023 Aug 30;2:1217065. doi: 10.3389/frtra.2023.1217065. eCollection 2023.

DOI:10.3389/frtra.2023.1217065

PMID:38993904

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11235334/

Abstract

CD4 Foxp3 regulatory T cells (Tregs) are indispensable for preventing autoimmunity, and they play a role in cancer and transplantation settings by restraining immune responses. In this review, we describe evidence for the importance of Tregs in the induction versus maintenance of transplantation tolerance, discussing insights into mechanisms of Treg control of the alloimmune response. Further, we address the therapeutic potential of Tregs as a clinical intervention after transplantation, highlighting engineered CAR-Tregs as well as expansion of donor and host Tregs.

摘要

CD4 Foxp3调节性T细胞（Tregs）对于预防自身免疫不可或缺，并且它们通过抑制免疫反应在癌症和移植环境中发挥作用。在本综述中，我们描述了Tregs在诱导与维持移植耐受中的重要性的证据，讨论了对Tregs控制同种异体免疫反应机制的见解。此外，我们探讨了Tregs作为移植后临床干预措施的治疗潜力，重点介绍了工程化嵌合抗原受体Tregs以及供体和宿主Tregs的扩增。