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用于异体胰岛移植的皮下微环境中间充质干细胞功能的免疫和血管生成分析

Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation.

作者信息

Campa-Carranza Jocelyn Nikita, Capuani Simone, Joubert Ashley L, Hernandez Nathanael, Bo Tommaso, Sauceda-Villanueva Octavio I, Conte Marzia, Franco Letizia, Farina Marco, Rome Gabrielle E, Xu Yitian, Zheng Junjun, Argueta Lissenya B, Niles Jean A, Nikolos Fotis, Chua Corrine Ying Xuan, Chen Shu-Hsia, Nichols Joan E, Kenyon Norma S, Grattoni Alessandro

机构信息

Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.

School of Medicine and Health Sciences, Tecnologico de Monterrey, Monterrey, NL, 64710, Mexico.

出版信息

Adv Sci (Weinh). 2025 May;12(20):e2411574. doi: 10.1002/advs.202411574. Epub 2025 May 8.

DOI:10.1002/advs.202411574
PMID:40344470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12120776/
Abstract

Islet transplantation offers a promising treatment for type 1 diabetes (T1D), by aiming to restore insulin production and improve glycemic control. However, T1D is compounded by impaired angiogenesis and immune dysregulation, which hinder the therapeutic potential of cell replacement strategies. To address this, this work evaluates the proangiogenic and immunomodulatory properties of mesenchymal stem cells (MSCs) to enhance vascularization and modulate early-stage immune rejection pathways in the context of islet allotransplantation. This work employs the Neovascularized Implantable Cell Homing and Encapsulation (NICHE) platform, a subcutaneous vascularized implant with localized immunomodulation developed by the group. This study assesses vascularization and immune regulation provided by MSCs, aiming to improve islet survival and integration in diabetic rats while considering sex as a biological variable. These findings demonstrate that MSCs significantly enhance vascularization and modulate the local microenvironment during the peri-transplant period. Importantly, this work discovers sex-specific differences in both processes, which influence islet engraftment and long-term function.

摘要

胰岛移植旨在恢复胰岛素分泌并改善血糖控制，为1型糖尿病（T1D）提供了一种有前景的治疗方法。然而，T1D合并有血管生成受损和免疫失调，这阻碍了细胞替代策略的治疗潜力。为了解决这一问题，本研究评估了间充质干细胞（MSCs）的促血管生成和免疫调节特性，以增强胰岛同种异体移植中的血管化并调节早期免疫排斥途径。本研究采用了新血管化可植入细胞归巢与封装（NICHE）平台，这是该研究团队开发的一种具有局部免疫调节功能的皮下血管化植入物。本研究评估了MSCs提供的血管化和免疫调节作用，旨在提高糖尿病大鼠胰岛的存活率和整合率，同时将性别作为一个生物学变量进行考虑。这些发现表明，MSCs在移植周围期显著增强了血管化并调节了局部微环境。重要的是，本研究发现这两个过程中存在性别特异性差异，这会影响胰岛的植入和长期功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4831/12120776/71c17aff4ed7/ADVS-12-2411574-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4831/12120776/71c17aff4ed7/ADVS-12-2411574-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4831/12120776/b71346b83163/ADVS-12-2411574-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4831/12120776/e0757b39d1d4/ADVS-12-2411574-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4831/12120776/fde24f4ba22e/ADVS-12-2411574-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4831/12120776/4f9e35c46a61/ADVS-12-2411574-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4831/12120776/04e9de28b3da/ADVS-12-2411574-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4831/12120776/60fe04d2a3cc/ADVS-12-2411574-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4831/12120776/71c17aff4ed7/ADVS-12-2411574-g004.jpg

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Bioeng Transl Med. 2024 Dec 13;10(3):e10740. doi: 10.1002/btm2.10740. eCollection 2025 May.
2
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead.利用细胞疗法治疗1型糖尿病：进展、挑战与未来之路。
Nat Rev Endocrinol. 2025 Jan;21(1):14-30. doi: 10.1038/s41574-024-01029-0. Epub 2024 Sep 3.
3
Using clusterProfiler to characterize multiomics data.
使用 clusterProfiler 对多组学数据进行特征分析。
Nat Protoc. 2024 Nov;19(11):3292-3320. doi: 10.1038/s41596-024-01020-z. Epub 2024 Jul 17.
4
Tregs in transplantation tolerance: role and therapeutic potential.调节性T细胞在移植耐受中的作用及治疗潜力。
Front Transplant. 2023 Aug 30;2:1217065. doi: 10.3389/frtra.2023.1217065. eCollection 2023.
5
Immunoprotection of cellular transplants for autoimmune type 1 diabetes through local drug delivery.通过局部药物递送实现细胞移植对 1 型自身免疫性糖尿病的免疫保护。
Adv Drug Deliv Rev. 2024 Mar;206:115179. doi: 10.1016/j.addr.2024.115179. Epub 2024 Jan 28.
6
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Adv Healthc Mater. 2025 Feb;14(5):e2304003. doi: 10.1002/adhm.202304003. Epub 2024 Jan 20.
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