Takahashi N, Fujita T, Takata Y, Tamura N
Clin Exp Immunol. 1985 Jul;61(1):176-82.
To clarify the biological activity of complement solubilized immune complexes, we studied their interaction with mouse peritoneal macrophages. The solubilized complexes lost their binding affinity for C3b receptor and Fc receptor but still bound to MPM mainly via the C3bi receptor (CR3). When solubilized immune complexes were injected into mice, they were more rapidly removed from the circulation than antigen excess soluble complexes and taken up by the liver Kupffer cells. Therefore, the solubilized complexes could be catabolized by the reticuloendothelial system, mainly in the liver. Probably, CR3 plays an important role in this process.
为阐明补体溶解免疫复合物的生物学活性，我们研究了它们与小鼠腹腔巨噬细胞的相互作用。溶解的复合物失去了对C3b受体和Fc受体的结合亲和力，但仍主要通过C3bi受体（CR3）与巨噬细胞结合。当将溶解的免疫复合物注射到小鼠体内时，它们从循环中清除的速度比抗原过量的可溶性复合物更快，并被肝脏库普弗细胞摄取。因此，溶解的复合物可被网状内皮系统，主要是在肝脏中分解代谢。可能，CR3在这个过程中起重要作用。
