De Tovar Jonathan, Leblay Rébecca, Wang Yongxing, Wojcik Laurianne, Thibon-Pourret Aurore, Réglier Marius, Simaan A Jalila, Le Poul Nicolas, Belle Catherine
Université Grenoble-Alpes, CNRS, Département de Chimie Moléculaire Grenoble France
Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, Institut des Sciences Moléculaires de Marseille Marseille France
Chem Sci. 2024 May 13;15(27):10308-10349. doi: 10.1039/d4sc01762e. eCollection 2024 Jul 10.
This review summarizes the latest discoveries in the field of C-H activation by copper monoxygenases and more particularly by their bioinspired systems. This work first describes the recent background on copper-containing enzymes along with additional interpretations about the nature of the active copper-oxygen intermediates. It then focuses on relevant examples of bioinorganic synthetic copper-oxygen intermediates according to their nuclearity (mono to polynuclear). This includes a detailed description of the spectroscopic features of these adducts as well as their reactivity towards the oxidation of recalcitrant C -H bonds. The last part is devoted to the significant expansion of heterogeneous catalytic systems based on copper-oxygen cores ( within zeolite frameworks).
本综述总结了单加氧铜酶领域,尤其是其仿生体系在C-H活化领域的最新发现。这项工作首先描述了含铜酶的近期研究背景,以及对活性铜-氧中间体性质的更多解释。然后根据其核数(单核到多核),重点介绍了生物无机合成铜-氧中间体的相关实例。这包括对这些加合物的光谱特征及其对顽固C-H键氧化反应活性的详细描述。最后一部分致力于基于铜-氧核(在沸石骨架内)的多相催化体系的显著扩展。