Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.
Dalian Hospital of Traditional Chinese Medicine, Dalian, Liaoning 116013, P.R. China.
Oncol Rep. 2024 Sep;52(3). doi: 10.3892/or.2024.8772. Epub 2024 Jul 12.
In recent years, microRNAs (miRNAs or miRs) have been increasingly studied for their role in cancer and have shown potential as cancer biomarkers. miR‑143‑3p and miR‑143‑5p are the mature miRNAs derived from pre‑miRNA‑143. At present, there are numerous studies on the function of miR‑143‑3p in cancer progression, but there are no systematic reviews describing the function of miR‑143‑3p in cancer. It is widely considered that miR‑143‑3p is downregulated in most malignant tumors and that upstream regulators can act on this gene, which in turn regulates the corresponding target to act on the tumor. In addition, miRNA‑143‑3p can regulate target genes to affect the biological process of tumors through various signaling pathways, such as the PI3K/Akt, Wnt/β‑catenin, AKT/STAT3 and Ras‑Raf‑MEK‑ERK pathways. The present review comprehensively described the biogenesis of miR‑143‑3p, the biological functions of miR‑143‑3p and the related roles and mechanisms in different cancer types. The potential of miR‑143‑3p as a biomarker for cancer was also highlighted and valuable future research directions were discussed.
近年来，微小 RNA（miRNAs 或 miR）因其在癌症中的作用而越来越受到关注，并已显示出作为癌症生物标志物的潜力。miR-143-3p 和 miR-143-5p 是源自前体 miRNA-143 的成熟 miRNA。目前，有许多关于 miR-143-3p 在癌症进展中的功能的研究，但没有系统的综述描述 miR-143-3p 在癌症中的功能。人们普遍认为，miR-143-3p 在大多数恶性肿瘤中下调，而上游调节剂可以作用于该基因，进而调节相应的靶标作用于肿瘤。此外，miRNA-143-3p 可以通过各种信号通路，如 PI3K/Akt、Wnt/β-catenin、AKT/STAT3 和 Ras-Raf-MEK-ERK 通路，调节靶基因来影响肿瘤的生物学过程。本综述全面描述了 miR-143-3p 的生物发生、miR-143-3p 的生物学功能以及在不同癌症类型中的相关作用和机制。还强调了 miR-143-3p 作为癌症生物标志物的潜力，并讨论了有价值的未来研究方向。
