Lesar T S, Fiscella R G
Drug Intell Clin Pharm. 1985 Sep;19(9):642-54. doi: 10.1177/106002808501900905.
A major obstacle in the treatment of ocular infections is the difficulty in obtaining adequate antimicrobial drug concentration at the site of infection. This article reviews the pharmacokinetic principles of ophthalmic drug delivery as it pertains to antimicrobial therapy. The administration of antimicrobials by topical application, subconjunctival injection, intravitreal injection, vitreous replacement fluid, and systemic administration are addressed. Representative data on the intraocular penetration of antimicrobials as well as recommended doses of drugs for ocular infections are presented.
眼部感染治疗中的一个主要障碍是在感染部位难以获得足够的抗菌药物浓度。本文回顾了与抗菌治疗相关的眼科药物递送的药代动力学原理。文中讨论了通过局部应用、结膜下注射、玻璃体内注射、玻璃体替代液和全身给药等方式使用抗菌药物的情况。还给出了抗菌药物眼内渗透的代表性数据以及眼部感染的推荐用药剂量。
