Department of Internal Medicine, Hepatology and Gastroenterology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Egypt J Immunol. 2024 Jul;31(3):81-94.
Inflammatory bowel disease is a chronic immune-mediated disorder with a relapsing and remitting course. It leads to disabling gastrointestinal symptoms, low quality of life, and a significant burden for healthcare utilization and associated costs. Therefore, non-invasive biomarkers are needed for early diagnosis and follow up to avoid the complications of invasive diagnostic procedures. Calgranulin C is a calcium binding protein with proinflammatory properties. The aim of this study was to evaluate the role of serum calgranulin C as a non-invasive biomarker for diagnosis and prediction of activity in comparison to different biomarkers and endoscopic activity scores in inflammatory bowel disease. The study included 80 inflammatory bowel disease patients (50 Ulcerative colitis and 30 Chron's patients) and 20 normal controls. Complete blood picture, C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin and serum calgranulin C were measured. Colonoscopies with histopathological examination were done and different activity scoring systems assessed. Among ulcerative colitis group, serum calgranulin C was statistically significantly higher in comparison to control group [723.640±529.055 ng/ml versus 80.850±24.416 ng/ml]. Depending on the American college of gastroenterology ulcerative colitis activity index, fecal calprotectin and serum calgranulin C were statistically significantly higher among moderate to severe ulcerative colitis than those with mild activity and those in remission (p < 0.001, for both). Regarding Crohn's disease group, serum calgranulin C was statistically significantly higher in comparison to control group [759.233±797.963 ng/ml versus 80.850±24.416 ng/mL]. Depending on Crohn's disease activity index, both serum calgranulin C and fecal calprotectin were statistically significantly higher among active disease than those in remission (p < 0.001, for both). In conclusion, serum calgranulin C could be used as a non-invasive marker to predict activity and severity and to ensure remission among inflammatory bowel disease patients.
炎症性肠病是一种慢性免疫介导的疾病，具有反复发作和缓解的特点。它会导致使人丧失能力的胃肠道症状、生活质量下降，并给医疗保健的利用和相关成本带来重大负担。因此，需要非侵入性的生物标志物来进行早期诊断和随访，以避免侵入性诊断程序的并发症。钙粒蛋白 C 是一种具有促炎特性的钙结合蛋白。本研究旨在评估血清钙粒蛋白 C 作为一种非侵入性生物标志物在炎症性肠病中的诊断和活动预测中的作用，并与其他生物标志物和内镜活动评分进行比较。该研究纳入了 80 名炎症性肠病患者（50 名溃疡性结肠炎和 30 名克罗恩病患者）和 20 名正常对照者。测量了全血细胞计数、C 反应蛋白、红细胞沉降率、粪便钙卫蛋白和血清钙粒蛋白 C。进行了结肠镜检查和组织病理学检查，并评估了不同的活动评分系统。在溃疡性结肠炎组中，与对照组相比，血清钙粒蛋白 C 显著升高[723.640±529.055ng/ml 与 80.850±24.416ng/ml]。根据美国胃肠病学会溃疡性结肠炎活动指数，中重度溃疡性结肠炎患者的粪便钙卫蛋白和血清钙粒蛋白 C 显著高于轻度活动和缓解期患者（均 P<0.001）。对于克罗恩病组，与对照组相比，血清钙粒蛋白 C 显著升高[759.233±797.963ng/ml 与 80.850±24.416ng/ml]。根据克罗恩病活动指数，活动期患者的血清钙粒蛋白 C 和粪便钙卫蛋白均显著高于缓解期患者（均 P<0.001）。总之，血清钙粒蛋白 C 可作为一种非侵入性标志物，用于预测炎症性肠病患者的活动和严重程度，并确保其缓解。
