Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany.
Department of Neurology, University Hospital of Cologne, Cologne, Germany.
J Parkinsons Dis. 2024;14(6):1271-1276. doi: 10.3233/JPD-240210.
In progressive supranuclear palsy (PSP), subcortical tau and cortical perfusion can be assessed using the tracer [18F]PI-2620. We investigated if subcortical tau (globus pallidus internus, dentate nucleus) and frontal/limbic perfusion correlate in a cohort of 32 PSP patients. Tau in subcortical regions showed significant negative correlation with perfusion in limbic cortex. Perfusion in frontal regions was negatively associated with tau in both subcortical regions, but the significance threshold was only passed for the dentate nucleus. A reason could be a diaschisis-like phenomenon; that is, subcortical tau could lead to reduced connectivity to frontal regions and, thereby, to decreased perfusion.
在进行性核上性麻痹（PSP）中，可以使用示踪剂 [18F]PI-2620 评估皮质下 tau 和皮质灌注。我们研究了 32 例 PSP 患者中皮质下 tau（苍白球内、齿状核）和额/边缘灌注是否存在相关性。皮质下区域的 tau 与边缘皮质的灌注呈显著负相关。额区的灌注与皮质下区域的 tau 均呈负相关，但仅在齿状核处达到显著性阈值。原因可能是一种类似于去神经支配的现象，即皮质下 tau 可能导致与额叶区域的连接减少，从而导致灌注减少。
