血缘关系对 iPSC 库设计的影响。
The impact of consanguinity on the design of iPSC banks.
机构信息
Abdulaziz International School, Riyadh, Saudi Arabia.
Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
出版信息
Stem Cell Reports. 2024 Aug 13;19(8):1043-1047. doi: 10.1016/j.stemcr.2024.06.004. Epub 2024 Jul 11.
The effect of consanguinity on identifying universal induced pluripotent stem cell (iPSC) donors, i.e., homozygous for the major human leukocyte antigen (HLA) loci, is unknown. The discovery sample size was calculated in a consanguineous population using a method (1qF) based on the inbreeding coefficient. The result was orders of magnitude smaller compared to the standard method.
血缘关系对鉴定通用诱导多能干细胞 (iPSC) 供体（即 HLA 主要基因座纯合子）的影响尚不清楚。使用基于近交系数的方法 (1qF) 在血缘关系人群中计算了发现样本量。与标准方法相比，结果小了几个数量级。
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