Greehey Children's Cancer Research Institute and Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Greehey Children's Cancer Research Institute and Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Structure. 2024 Jul 11;32(7):854-855. doi: 10.1016/j.str.2024.06.007.
In a recent issue of Nature Chemical Biology, Emmanouilidis et al. (2024) investigate the maturation of biomolecular condensates of FUS and probe the molecular details of droplet aging. They observe that the liquid-to-solid transition of the droplet is mediated at the surface by FUS molecules that have adopted β-strand conformations.
在最近一期的《自然-化学生物学》杂志上，Emmanouilidis 等人（2024 年）研究了 FUS 生物分子凝聚物的成熟过程，并探究了液滴老化的分子细节。他们观察到，液滴的液相到固相转变是由采用 β-折叠构象的 FUS 分子在表面介导的。
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