Subhan Z, Hindmarch I
Eur J Clin Pharmacol. 1985;28(5):567-71. doi: 10.1007/BF00544068.
Twelve healthy female volunteers received pre-treatments with vinpocetine 10, 20, 40 mg and placebo (t.d.s.) for two days according to a randomised, double-blind crossover design. On the third day of treatment and 1 h following morning dosage, subjects completed a battery of psychological tests including Critical Flicker Fusion (CFF), Choice Reaction Time (CRT), Subjective Ratings of Drug Effects (LARS) and a Sternberg Memory Scanning Test. No statistically significant changes from placebo were observed on CFF, CRT or subjective ratings of drug effects. However, memory as assessed using the Sternberg technique was found to be significantly improved following treatment with vinpocetine 40 mg when compared to placebo and results suggested a localised effect of the drug on the serial comparison stage of the reaction process.
12名健康女性志愿者按照随机、双盲交叉设计，接受了为期两天的长春西汀10毫克、20毫克、40毫克及安慰剂（每日三次）预处理。在治疗的第三天及早晨服药1小时后，受试者完成了一系列心理测试，包括临界闪烁融合频率（CFF）、选择反应时间（CRT）、药物效果主观评分（LARS）以及斯特恩伯格记忆扫描测试。在CFF、CRT或药物效果主观评分方面，未观察到与安慰剂相比有统计学显著差异。然而，与安慰剂相比，使用斯特恩伯格技术评估发现，服用40毫克长春西汀治疗后记忆力有显著改善，结果表明该药物对反应过程的序列比较阶段有局部作用。
