依巴斯汀：一种新型抗组胺药对健康受试者精神运动表现和自主神经反应的影响。
Ebastine: the effect of a new antihistamine on psychomotor performance and autonomic responses in healthy subjects.
作者信息
Vincent J, Sumner D J, Reid J L
机构信息
University Department of Materia Medica, Stobhill General Hospital, Glasgow.
出版信息
Br J Clin Pharmacol. 1988 Nov;26(5):503-8. doi: 10.1111/j.1365-2125.1988.tb05289.x.
Abstract
- Ebastine, through its carboxylic acid metabolite has antihistamine (H1-receptor) activity in man. 2. We have examined in a single blind placebo controlled study the effects of 10 mg and 50 mg of ebastine on cardiovascular, autonomic and psychomotor function in healthy subjects. 3. Ebastine had no effect on blood pressure or heart rate and there was no evidence of any anticholinergic activity on circulatory reflexes or salivation. 4. Ebastine did not impair psychomotor performance as assessed by critical flicker fusion at either dose. 5. Ebastine 10 mg had no effect on sedation measured by visual analogue scale or direct questioning, however ebastine 50 mg did cause a modest increase in indices of sedation. 6. Ebastine did not have detectable sedative properties at the 10 mg dose where long-lasting antihistamine effects can be demonstrated.
摘要
- 依巴斯汀通过其羧酸代谢物在人体中具有抗组胺（H1受体）活性。2. 我们在一项单盲安慰剂对照研究中，考察了10毫克和50毫克依巴斯汀对健康受试者心血管、自主神经和精神运动功能的影响。3. 依巴斯汀对血压或心率无影响，也没有证据表明其对循环反射或唾液分泌有任何抗胆碱能活性。4. 两种剂量的依巴斯汀均未通过临界闪烁融合评估损害精神运动表现。5. 10毫克依巴斯汀对通过视觉模拟量表或直接询问测量的镇静作用无影响，然而50毫克依巴斯汀确实导致镇静指标有适度增加。6. 在10毫克剂量下依巴斯汀没有可检测到的镇静特性，而在此剂量下可证明有持久的抗组胺作用。
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