Jin N R, Hill R S, Petersen F B, Buckner C D, Stewart P S, Amos D, Appelbaum F R, Clift R A, Bensinger W I, Sanders J E
Exp Hematol. 1985 Oct;13(9):879-84.
The results and complications of 224 marrow collections from 200 patients with malignant disease who underwent marrow aspiration and storage for subsequent autologous marrow transplantation (AMT) were analyzed. The median age of the patients was 35 years (range 1-68); 131 patients had hematologic malignancies and 69 had solid tumors. Thirty-one patients proceeded directly to AMT after marrow aspiration at a median of 4.5 days (range 0-10). A further 75 patients received AMT a median of 3.0 months (12 days-10 years) after marrow aspiration. The remaining 94 patients had marrow stored but not infused. When a second aspiration was performed from the same patient within seven weeks, the yield of marrow nucleated cells was significantly reduced (p less than 0.02). A negative linear correlation was observed between CFU-C/kg harvested and the day to achieve a posttransplant blood neutrophil count greater than 500/cmm (r = -0.3092, p less than 0.05). A total of 36 (17.4%) complications associated with marrow aspiration were observed including two (0.97%) life-threatening episodes. Postoperative fever accounted for 23 of 34 episodes of minor complications. There was no increased risk of serious complications with decreased time from aspiration to transplant. It was concluded that the morbidity and mortality from autologous marrow aspiration did not differ significantly from that observed in normal donors.
对200例患有恶性疾病的患者进行骨髓穿刺并储存以备后续自体骨髓移植（AMT），共进行了224次骨髓采集，分析了其结果及并发症。患者的中位年龄为35岁（范围1 - 68岁）；131例患者患有血液系统恶性肿瘤，69例患有实体瘤。31例患者在骨髓穿刺后中位4.5天（范围0 - 10天）直接进行AMT。另外75例患者在骨髓穿刺后中位3.0个月（12天 - 10年）接受AMT。其余94例患者的骨髓被储存但未输注。当在7周内对同一患者进行第二次穿刺时，骨髓有核细胞产量显著降低（p < 0.02）。观察到每千克收获的CFU - C与移植后血液中性粒细胞计数大于500/cmm所需天数之间呈负线性相关（r = -0.3092，p < 0.05）。共观察到36例（17.4%）与骨髓穿刺相关的并发症，包括2例（0.97%）危及生命的情况。术后发热占34例轻微并发症中的23例。从穿刺到移植时间缩短，严重并发症风险并未增加。得出结论，自体骨髓穿刺的发病率和死亡率与正常供体观察到的情况无显著差异。
