Bo P, Savoldi F, Tartara A
Farmaco Sci. 1979 Jul;34(7):621-7.
In this paper we report our results concerning the antagonism between dopaminergic (bromocriptine, apomorphine, piribedil) and neuroleptic (haloperidol, chlorpromazine, reserpine, clotiapine) drugs on the eeg and behaviour of rabbits. The Monnier and Gangloff stereotaxic method was used in order to record cortical and deep structures. The use of neurophysiologic methods also enabled us to verify the magnitude and modes of the antagonism between the two types of drugs. Particularly, the dissociation between eeg and behavioural effects of this antagonism is discussed; this fact seems to confirm the hypothesis that dopaminergic drugs have a double point of attack in the CNS.
在本文中，我们报告了关于多巴胺能药物（溴隐亭、阿扑吗啡、匹立地尔）与抗精神病药物（氟哌啶醇、氯丙嗪、利血平、氯噻平）对家兔脑电图及行为的拮抗作用的研究结果。采用莫尼尔和甘格洛夫立体定位法记录皮层和深部结构。神经生理学方法的运用还使我们能够验证这两类药物之间拮抗作用的强度和方式。特别讨论了这种拮抗作用在脑电图和行为效应之间的分离；这一事实似乎证实了多巴胺能药物在中枢神经系统有双靶点攻击的假说。
