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海参烹饪液中的硫酸化多糖通过调节高脂饮食小鼠的肠道微生物群、转录组和代谢物谱来预防肥胖。

Sulfated Polysaccharides from Sea Cucumber Cooking Liquid Prevents Obesity by Modulating Gut Microbiome, Transcriptome, and Metabolite Profiles in Mice Fed a High-Fat Diet.

作者信息

Sang Xue, Guan Xin, Tong Yao, Wang Fuyi, Zhou Boqian, Li Ying, Zhao Qiancheng

机构信息

College of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China.

Dalian Key Laboratory of Marine Bioactive Substances Development and High-Value Utilization, Dalian 116023, China.

出版信息

Foods. 2024 Jun 26;13(13):2017. doi: 10.3390/foods13132017.

DOI:10.3390/foods13132017
PMID:38998524
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11241695/
Abstract

We aimed to explore the anti-obesity mechanism from the microbiome, metabolome, and transcriptome viewpoints, focusing on the sulfated polysaccharides found in the cooking liquid of (CLSP) to explore the potential mediators of the anti-obesity effects in mice fed a high-fat diet (HFD). The mice treated with CLSP showed a decrease in obesity and blood lipid levels. Gut microbiome dysbiosis caused by the HFD was reversed after CLSP supplementation, along with increased levels of indole-3-ethanol, N-2-succinyl-L-glutamic acid 5-semialdehyde, and urocanic acid. These increases were positively related to the increased , , , and . Transcriptome analysis showed that B cell receptor signaling and cytochrome P450 xenobiotic metabolism were the main contributors to the improvement in obesity. Metabolome-transcriptome analysis revealed that CLSP reversal of obesity was mainly due to amino acid metabolism. These findings suggest that CLSP could be a valuable prebiotic preparation for preventing obesity-related diseases.

摘要

我们旨在从微生物组、代谢组和转录组的角度探索抗肥胖机制，重点关注在[具体食物名称]烹饪液中发现的硫酸化多糖（CLSP），以探究高脂饮食（HFD）喂养小鼠中抗肥胖作用的潜在介质。用CLSP处理的小鼠肥胖和血脂水平降低。补充CLSP后，HFD引起的肠道微生物群失调得到逆转，同时吲哚 - 3 - 乙醇、N - 2 - 琥珀酰 - L - 谷氨酸5 - 半醛和尿刊酸水平升高。这些增加与[具体基因名称]、[具体基因名称]、[具体基因名称]和[具体基因名称]的增加呈正相关。转录组分析表明，B细胞受体信号传导和细胞色素P450异源生物代谢是肥胖改善的主要因素。代谢组 - 转录组分析表明，CLSP对肥胖的逆转主要归因于氨基酸代谢。这些发现表明，CLSP可能是预防肥胖相关疾病的有价值的益生元制剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/1e301faaae05/foods-13-02017-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/5388a9ea2cab/foods-13-02017-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/61703b106380/foods-13-02017-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/51f1eb52c96c/foods-13-02017-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/f483acf9acf7/foods-13-02017-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/0cc838de5f35/foods-13-02017-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/d6fa748e8166/foods-13-02017-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/c5874c635410/foods-13-02017-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/e2d262c8be27/foods-13-02017-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/1e301faaae05/foods-13-02017-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/5388a9ea2cab/foods-13-02017-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/61703b106380/foods-13-02017-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/51f1eb52c96c/foods-13-02017-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/f483acf9acf7/foods-13-02017-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/0cc838de5f35/foods-13-02017-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/d6fa748e8166/foods-13-02017-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/c5874c635410/foods-13-02017-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/e2d262c8be27/foods-13-02017-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d50/11241695/1e301faaae05/foods-13-02017-g009.jpg

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