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从金属饮料罐内涂层中可提取的最常见潜在迁移物的质谱研究。

Mass Spectrometric Study of the Most Common Potential Migrants Extractible from the Inner Coatings of Metallic Beverage Cans.

作者信息

Beszterda-Buszczak Monika, Kasperkowiak Małgorzata, Teżyk Artur, Augustynowicz Natalia, Frański Rafał

机构信息

Department of Food Biochemistry and Analysis, Poznań University of Life Sciences, Mazowiecka 48, 60-623 Poznań, Poland.

Centre for Advanced Technologies, Adam Mickiewicz University, Uniwersytetu Poznańskiego 10, 61-614 Poznań, Poland.

出版信息

Foods. 2024 Jun 26;13(13):2025. doi: 10.3390/foods13132025.

DOI:10.3390/foods13132025
PMID:38998531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11241440/
Abstract

Population exposure to endocrine disrupting chemical- bisphenols, which are used commonly in food containers and drinking water pipes in Europe, is above acceptable health and safety levels, according to updated research data. In order to evaluate the most abundant potential migrants in canned sweetened beverages marketed in Poland, we performed the HPLC-MS screening test of the migrants present in the can coating material. The analyzed samples represented the three top-ranked companies of the global soft drink market; it is reasonable to assume that the obtained data are of global validity. The tested can coatings and beverages contained bisphenols conjugates such as five butoxyethanol (BuOEtOH) adducts with bisphenol A diglycidyl ether (BADGE), one butoxyethanol adduct with bisphenol A monoglycidyl ether (BAMGE), and cyclo-di-BADGE. The performed HPLC-MS/MS analysis in the MRM mode enabled evaluation of the concentrations of the detected conjugates in canned beverages which were found to be very low, namely at the level of 1 µg/L. On the other hand, the high consumption of canned beverages may yield a risk associated with the presence of these compounds in the diet. The subsequent HPLC-QTOF-MS/MS experiments allowed, for the first time, a detailed determination of the fragmentation pathways of the detected migrants as well as detection of the isomers of the two migrants, namely BADGE + BuOEtOH and BADGE + BuOEtOH + HCl.

摘要

根据最新研究数据，欧洲食品容器和饮用水管道中普遍使用的内分泌干扰化学物质双酚类，导致人群暴露水平高于可接受的健康与安全标准。为评估波兰市场上罐装甜味饮料中最主要的潜在迁移物，我们对罐内涂层材料中的迁移物进行了HPLC-MS筛选测试。所分析的样品代表了全球软饮料市场排名前三的公司；因此可以合理推断所获数据具有全球有效性。测试的罐内涂层和饮料中含有双酚类共轭物，如五种丁氧基乙醇（BuOEtOH）与双酚A二缩水甘油醚（BADGE）的加合物、一种丁氧基乙醇与双酚A单缩水甘油醚（BAMGE）的加合物以及环二BADGE。在MRM模式下进行的HPLC-MS/MS分析能够评估罐装饮料中所检测到的共轭物浓度，结果发现其浓度非常低，即处于1 µg/L的水平。另一方面，罐装饮料的高消费量可能会带来与这些化合物在饮食中存在相关的风险。随后的HPLC-QTOF-MS/MS实验首次详细确定了所检测到的迁移物的裂解途径，并检测到了两种迁移物的异构体，即BADGE + BuOEtOH和BADGE + BuOEtOH + HCl。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/58574885f4c5/foods-13-02025-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/58b01336b8eb/foods-13-02025-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/a16c087c5808/foods-13-02025-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/e578e22e1901/foods-13-02025-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/4174807cd063/foods-13-02025-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/0b8db2519ddf/foods-13-02025-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/58574885f4c5/foods-13-02025-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/58b01336b8eb/foods-13-02025-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/a16c087c5808/foods-13-02025-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/e578e22e1901/foods-13-02025-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/4174807cd063/foods-13-02025-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/0b8db2519ddf/foods-13-02025-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7206/11241440/58574885f4c5/foods-13-02025-g006.jpg

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