Hammarling L, Gustavsson H, Svensson K, Oskarsson A
National Food Administration, Box 622, SE-751 26 Uppsala, Sweden.
Food Addit Contam. 2000 Nov;17(11):937-43. doi: 10.1080/026520300750038126.
Bisphenol-A diglycidyl ether (BADGE) is used as an additive or starting agent in coatings for cans. The presence of hydrochloric acid in the organosol (PVC-based) lacquers results in formation of chlorohydroxy compounds of BADGE. These compounds, as well as BADGE itself, are potential migrants into the preserved food and are of toxicological concern. In the present investigation the presence of BADGE and the chlorohydroxy compounds (BADGE.HCl and BADGE.2HCl) in various kinds of canned foods from 30 brands have been determined by HPLC with fluorescence detection. BADGE was found in levels up to 5.1 mg/kg in the food and only in food from cans containing BADGE.HCl and BADGE.2HCl in the lacquers. BADGE was found both in fish in oil and in fish in tomato sauce, however, the highest amounts were found in the fatty foodstuffs. BADGE.HCl and BADGE.2HCl were found in concentrations up to 2.4 mg/kg and 8.3 mg/kg, respectively. Unlike BADGE, BADGE.2HCl was found in similar concentrations in fish in oil and in fish in tomato sauce. In aqueous and acidic foodstuffs BADGE readily hydrolyses into mono- and dihydrolysed products (BADGE.H2O and BADGE.2H2O). In this study BADGE.H2O was not found in any food sample, whereas BADGE.2H2O was found in levels up to 2.6 mg/kg. The Scientific Committee for Food (SCF) of the European Commission has proposed that a limit of restriction of 1 mg/kg food shall include BADGE itself and BADGE.H2O, BADGE.HCl, BADGE.2HCl and BADGE.HCL.H2O. The present results indicate that the migration of BADGE.HCl and BADGE.2HCl, compounds with almost no data on toxicity, implies a greater problem than BADGE.H2O and BADGE.2H2O.
双酚A二缩水甘油醚（BADGE）用作罐装涂料的添加剂或起始剂。有机溶胶（聚氯乙烯基）漆中盐酸的存在会导致BADGE形成氯羟基化合物。这些化合物以及BADGE本身都有可能迁移到保存的食品中，因此存在毒理学问题。在本研究中，采用带荧光检测的高效液相色谱法测定了30个品牌的各类罐装食品中BADGE和氯羟基化合物（BADGE.HCl和BADGE.2HCl）的含量。在食品中发现BADGE的含量高达5.1 mg/kg，且仅在漆中含有BADGE.HCl和BADGE.2HCl的罐装食品中存在。在油浸鱼和番茄酱鱼中均发现了BADGE，但脂肪类食品中的含量最高。BADGE.HCl和BADGE.2HCl的浓度分别高达2.4 mg/kg和8.3 mg/kg。与BADGE不同，油浸鱼和番茄酱鱼中BADGE.2HCl的浓度相似。在水性和酸性食品中，BADGE很容易水解为单水解和双水解产物（BADGE.H2O和BADGE.2H2O）。在本研究中，任何食品样品中均未发现BADGE.H2O，而BADGE.2H2O的含量高达2.6 mg/kg。欧盟委员会食品科学委员会（SCF）提议，食品中1 mg/kg的限制范围应包括BADGE本身、BADGE.H2O、BADGE.HCl、BADGE.2HCl和BADGE.HCL.H2O。目前的结果表明，几乎没有毒性数据的化合物BADGE.HCl和BADGE.2HCl的迁移所带来的问题比BADGE.H2O和BADGE.2H2O更大。
