Khanna Aman, Vaidya Krish, Shah Dharmesh, Ranjan Amaresh K, Gulati Anil
Aman Hospital and Research Centre Organization, Vadodara 390021, GJ, India.
I Cure Heart Care, Vadodara 390007, GJ, India.
J Clin Med. 2024 Jun 27;13(13):3765. doi: 10.3390/jcm13133765.
Centhaquine is a resuscitative agent that acts on α2B adrenergic receptors. Its effect on cardiac output in hypovolemic shock patients has not been reported. This pilot study was conducted in 12 hypovolemic shock patients treated with centhaquine who participated in an open-label phase IV study (NCT05956418). Echocardiography was utilized to measure stroke volume (SV), cardiac output (CO), left ventricular outflow tract velocity time integral (LVOT-VTI) and diameter (LVOTd), heart rate (HR), left ventricular ejection fraction (LVEF) and fractional shortening (LVFS), and inferior vena cava (IVC) diameter before (0 min) and 60, 120, and 300 min after centhaquine (0.01 mg/kg) iv infusion for 60 min. : SV was significantly increased after 60, 120, and 300 min. CO increased significantly after 120 and 300 min despite a decrease in HR. IVC diameter and LVOT-VTI at these time points significantly increased, indicating the increased venous return. LVEF and LVFS did not change, while the mean arterial pressure (MAP, mmHg) increased after 120 and 300 min. Positive correlations between IVC diameter and SV (R = 0.9556) and between IVC diameter and MAP (R = 0.8928) were observed, which indicated the effects of an increase in venous return on SV, CO, and MAP. : Centhaquine-mediated increase in venous return is critical in enhancing SV, CO, and MAP in patients with hypovolemic shock; these changes could be pivotal for reducing shock-mediated circulatory failure, promoting tissue perfusion, and improving patient outcomes. : CTRI/2021/01/030263 and NCT05956418.
喷他喹是一种作用于α2B肾上腺素能受体的复苏药物。其对低血容量性休克患者心输出量的影响尚未见报道。本前瞻性研究纳入了12例接受喷他喹治疗的低血容量性休克患者，这些患者参与了一项开放标签的IV期研究（NCT05956418）。采用超声心动图测量喷他喹（0.01mg/kg）静脉输注60分钟前（0分钟）以及输注后60、120和300分钟时的每搏输出量（SV）、心输出量（CO）、左心室流出道速度时间积分（LVOT-VTI）和直径（LVOTd）、心率（HR）、左心室射血分数（LVEF）和缩短分数（LVFS），以及下腔静脉（IVC）直径。结果显示，输注后60、120和300分钟时SV显著增加。尽管HR下降，但CO在输注后120和300分钟时显著增加。这些时间点的IVC直径和LVOT-VTI显著增加，表明静脉回流增加。LVEF和LVFS未发生变化，而平均动脉压（MAP，mmHg）在输注后120和300分钟时升高。观察到IVC直径与SV（R = 0.9556）以及IVC直径与MAP（R = 0.8928）之间呈正相关，这表明静脉回流增加对SV、CO和MAP的影响。结论：喷他喹介导的静脉回流增加对于提高低血容量性休克患者的SV、CO和MAP至关重要；这些变化可能对减少休克介导的循环衰竭、促进组织灌注和改善患者预后起到关键作用。试验注册号：CTRI/2021/01/030263和NCT05956418。
