Wilson R A, Okada R D, Barlai-Kovach M, Strauss H W
Int J Nucl Med Biol. 1985;12(2):97-101. doi: 10.1016/0047-0740(85)90163-9.
Intravenous infusion of glucose-insulin-potassium (GIK) has been shown to alter the net rate of clearance of 201Tl from transiently ischemic and normally perfused canine myocardium. This study was performed to determine if GIK would also decrease the extent of thallium redistribution after transient myocardial ischemia. Six anesthetized, open-chest dogs underwent two studies, one with GIK and another with saline infusion. The left anterior descending coronary artery was occluded, 201Tl injected, and the occlusion released 5-min later. An i.v. infusion of either GIK (4 dogs) or saline (2 dogs) was then begun and continued for the 120-min duration of serial myocardial imaging using a standard scintillation camera. The experiment was then repeated with an infusion of saline (4 dogs) or GIK (2 dogs). The dose of 201Tl for the second study was at least 5 times more than was used for the first study. The serial 2-min images were then displayed on computer and regions of interest were drawn over the areas of transient ischemia (TI) and normal perfusion (NP). The ratio of average counts per picture element for the area of TI compared to NP was calculated. One hundred and twenty minutes after 201Tl administration, the change in the TI/NP ratio (% fill-in) was significantly less for the GIK infusion compared to saline infusion (control) 15.4 +/- 4.0% vs 26.2 +/- 6.0% (mean +/- SE) (P less than 0.01), respectively. Therefore, GIK infusion appeared to decrease the extent of thallium redistribution compared to saline control.
静脉输注葡萄糖 - 胰岛素 - 钾（GIK）已被证明可改变201Tl从短暂缺血和正常灌注的犬心肌中的净清除率。本研究旨在确定GIK是否也会减少短暂性心肌缺血后铊的再分布程度。对6只麻醉开胸犬进行了两项研究，一项使用GIK，另一项使用生理盐水输注。结扎左前降支冠状动脉，注射201Tl，5分钟后松开结扎。然后开始静脉输注GIK（4只犬）或生理盐水（2只犬），并在使用标准闪烁相机进行120分钟的连续心肌成像期间持续输注。然后用生理盐水（4只犬）或GIK（2只犬）输注重复该实验。第二项研究中201Tl的剂量至少是第一项研究中使用剂量的5倍以上。然后将连续的2分钟图像显示在计算机上，并在短暂缺血（TI）和正常灌注（NP）区域绘制感兴趣区。计算TI区域与NP区域每个象素平均计数的比率。给予201Tl后120分钟，与生理盐水输注（对照）相比，GIK输注的TI/NP比率变化（%填充）明显更小，分别为15.4±4.0% 对26.2±6.0%（平均值±标准误）（P<0.01）。因此，与生理盐水对照相比，GIK输注似乎减少了铊的再分布程度。
