Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, 8603 Schwerzenbach, Switzerland.
Mibelle Group Biochemistry, Mibelle AG, 5033 Buchs, Switzerland.
Nutrients. 2024 Jul 3;16(13):2122. doi: 10.3390/nu16132122.
Investigations into human longevity are increasingly focusing on healthspan enhancement, not just lifespan extension. Lifestyle modifications and nutritional choices, including food supplements, can significantly affect aging and general health. Phytochemicals in centenarians' diets, such as those found in Timut pepper, a Nepalese spice with various medicinal properties, may contribute to their longevity. Similarly, Sichuan pepper, a related species, has demonstrated anti-inflammatory and neuroprotective activities. With the broader purpose of uncovering a novel treatment to address aging and its comorbidities, this study aims to investigate the potential lifespan- and healthspan-promoting effects of Timut pepper using the model organism We show that Timut pepper extract extends lifespan at different maintenance temperatures and increases the proportion of active nematodes in their early adulthood. In addition, we show that Timut pepper extract enhances speed and distance moved as the nematodes age. Finally, Timut pepper extract assures extracellular matrix homeostasis by slowing the age-dependent decline of collagen expression.
对人类长寿的研究越来越关注于健康寿命的延长，而不仅仅是寿命的延长。生活方式的改变和营养选择，包括食物补充剂，可以显著影响衰老和整体健康。百岁老人饮食中的植物化学物质，如尼泊尔香料蒂玛特胡椒中发现的那些，可能有助于他们的长寿。同样，四川花椒，一种相关的物种，具有抗炎和神经保护活性。本研究旨在以模型生物为研究对象，探索蒂玛特胡椒提取物作为一种新型治疗方法来应对衰老及其合并症的潜力，我们发现蒂玛特胡椒提取物可以延长不同维持温度下的寿命，并增加其在早期成年期的活性线虫比例。此外，我们还发现蒂玛特胡椒提取物可以增强线虫随着年龄增长的速度和移动距离。最后，蒂玛特胡椒提取物通过减缓胶原蛋白表达随年龄下降来确保细胞外基质的稳态。
