State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangzhou 510642, China.
Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China.
Int J Mol Sci. 2024 Jun 21;25(13):6836. doi: 10.3390/ijms25136836.
Bri1-EMS Suppressor 1 (BES1) and Brassinazole Resistant 1 (BZR1) are two key transcription factors in the brassinosteroid (BR) signaling pathway, serving as crucial integrators that connect various signaling pathways in plants. Extensive genetic and biochemical studies have revealed that BES1 and BZR1, along with other protein factors, form a complex interaction network that governs plant growth, development, and stress tolerance. Among the interactome of BES1 and BZR1, several proteins involved in posttranslational modifications play a key role in modifying the stability, abundance, and transcriptional activity of BES1 and BZR1. This review specifically focuses on the functions and regulatory mechanisms of BES1 and BZR1 protein interactors that are not involved in the posttranslational modifications but are crucial in specific growth and development stages and stress responses. By highlighting the significance of the BZR1 and BES1 interactome, this review sheds light on how it optimizes plant growth, development, and stress responses.
Bri1-EMS Suppressor 1 (BES1) 和 Brassinazole Resistant 1 (BZR1) 是油菜素内酯（BR）信号通路中的两个关键转录因子，作为连接植物中各种信号通路的关键整合因子。广泛的遗传和生化研究表明，BES1 和 BZR1 与其他蛋白因子一起，形成了一个复杂的相互作用网络，调控着植物的生长、发育和胁迫耐受。在 BES1 和 BZR1 的互作组中，一些涉及翻译后修饰的蛋白在修饰 BES1 和 BZR1 的稳定性、丰度和转录活性方面发挥着关键作用。本综述特别关注不涉及翻译后修饰但在特定生长和发育阶段以及应激反应中至关重要的 BES1 和 BZR1 蛋白互作因子的功能和调控机制。通过强调 BZR1 和 BES1 互作组的重要性，本综述揭示了它如何优化植物的生长、发育和应激反应。
