Doctorado en Ciencias mención Biología Celular y Molecular Aplicada, Facultad de Ciencias Agropecuarias, Universidad de La Frontera, Temuco 4811230, Chile.
Departamento de Ciencias Preclínicas, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile.
Int J Mol Sci. 2024 Jun 27;25(13):7084. doi: 10.3390/ijms25137084.
Alzheimer's disease is a pathology characterized by the progressive loss of neuronal connections, which leads to gray matter atrophy in the brain. Alzheimer's disease is the most prevalent type of dementia and has been classified into two types, early onset, which has been associated with genetic factors, and late onset, which has been associated with environmental factors. One of the greatest challenges regarding Alzheimer's disease is the high economic cost involved, which is why the number of studies aimed at prevention and treatment have increased. One possible approach is the use of resistance exercise training, given that it has been shown to have neuroprotective effects associated with Alzheimer's disease, such as increasing cortical and hippocampal volume, improving neuroplasticity, and promoting cognitive function throughout the life cycle. However, how resistance exercise training specifically prevents or ameliorates Alzheimer's disease has not been fully characterized. Therefore, the aim of this review was to identify the molecular basis by which resistance exercise training could prevent or treat Alzheimer's disease.
阿尔茨海默病是一种以神经元连接渐进性丧失为特征的病理学，这导致大脑灰质萎缩。阿尔茨海默病是最常见的痴呆症类型，已分为两种类型，即早发性，与遗传因素有关，和晚发性，与环境因素有关。关于阿尔茨海默病的最大挑战之一是其涉及的高经济成本，这就是为什么旨在预防和治疗的研究数量增加的原因。一种可能的方法是使用抗阻运动训练，因为已经表明它具有与阿尔茨海默病相关的神经保护作用，例如增加皮质和海马体体积、改善神经可塑性以及促进整个生命周期的认知功能。然而，抗阻运动训练如何具体预防或改善阿尔茨海默病尚未完全阐明。因此，本综述的目的是确定抗阻运动训练可以预防或治疗阿尔茨海默病的分子基础。
