College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Yuelushan Laboratory, Changsha 410128, China.
Int J Mol Sci. 2024 Jun 29;25(13):7175. doi: 10.3390/ijms25137175.
Obesity is a global health challenge that has received increasing attention in contemporary research. The gut microbiota has been implicated in the development of obesity, primarily through its involvement in regulating various host metabolic processes. Recent research suggests that epigenetic modifications may serve as crucial pathways through which the gut microbiota and its metabolites contribute to the pathogenesis of obesity and other metabolic disorders. Hence, understanding the interplay between gut microbiota and epigenetic mechanisms is crucial for elucidating the impact of obesity on the host. This review primarily focuses on the understanding of the relationship between the gut microbiota and its metabolites with epigenetic mechanisms in several obesity-related pathogenic mechanisms, including energy dysregulation, metabolic inflammation, and maternal inheritance. These findings could serve as novel therapeutic targets for probiotics, prebiotics, and fecal microbiota transplantation tools in treating metabolic disruptions. It may also aid in developing therapeutic strategies that modulate the gut microbiota, thereby regulating the metabolic characteristics of obesity.
肥胖是一个全球性的健康挑战，在当代研究中受到越来越多的关注。肠道微生物群已被牵涉到肥胖的发展中，主要是通过其参与调节各种宿主代谢过程。最近的研究表明，表观遗传修饰可能是肠道微生物群及其代谢物导致肥胖和其他代谢紊乱发病机制的关键途径。因此，了解肠道微生物群和表观遗传机制之间的相互作用对于阐明肥胖对宿主的影响至关重要。这篇综述主要关注理解肠道微生物群及其代谢物与几种肥胖相关发病机制中的表观遗传机制之间的关系，包括能量失调、代谢炎症和母系遗传。这些发现可能为益生菌、益生元和粪便微生物群移植工具在治疗代谢紊乱方面提供新的治疗靶点。它还可能有助于开发调节肠道微生物群从而调节肥胖代谢特征的治疗策略。
