Azari Hushyar, George Megan, Albracht-Schulte Kembra
Department of Kinesiology and Sport Management and Obesity Research Institute, Texas Tech University, Lubbock, TX 79409, USA.
Int J Mol Sci. 2024 Nov 29;25(23):12836. doi: 10.3390/ijms252312836.
Obesity is the fifth leading cause of death globally and its comorbidities put a high burden on societies and cause disability. In this review, we aim to summarize the interactions and crosstalk between gut microbiota and micro-RNA (miRNA) in obesity. We searched for the relevant literature through PubMed, Web of Science, Scopus, and Science Direct. The study design is registered in the international prospective register of systematic reviews (Prospero). According to the inclusion criteria, eight studies were eligible for assessment (two studies including human subjects and six studies including animal subjects). We report that the interactions of miRNA and gut microbiota in the context of obesity are diverse and in some cases tissue specific. However, the interactions mediate obesity-associated pathways including the inflammatory response, oxidative stress, insulin signaling, gut permeability, and lipogenesis. To mention the most meaningful results, the expression of adipose tissue miRNA-378a-3p/5p was associated with and abundance, the expression of hepatic miRNA-34a was related to the phylum, and the expression of miRNA-122-5p and miRNA-375 was associated with the genus. miRNA-microbiota-associated pathological pathways seem to provide an intricate, but promising field for future research directed toward the treatment of obesity and its comorbidities.
肥胖是全球第五大死因，其合并症给社会带来沉重负担并导致残疾。在本综述中，我们旨在总结肥胖症中肠道微生物群与微小RNA（miRNA）之间的相互作用和串扰。我们通过PubMed、Web of Science、Scopus和ScienceDirect搜索了相关文献。该研究设计已在国际系统评价前瞻性注册库（Prospero）中注册。根据纳入标准，八项研究符合评估条件（两项研究涉及人类受试者，六项研究涉及动物受试者）。我们报告称，在肥胖症背景下，miRNA与肠道微生物群的相互作用多种多样，在某些情况下具有组织特异性。然而，这些相互作用介导了与肥胖相关的途径，包括炎症反应、氧化应激、胰岛素信号传导、肠道通透性和脂肪生成。为了提及最有意义的结果，脂肪组织miRNA-378a-3p/5p的表达与[具体内容1]丰度相关，肝脏miRNA-34a的表达与[具体内容2]门相关，miRNA-122-5p和miRNA-375的表达与[具体内容3]属相关。miRNA-微生物群相关的病理途径似乎为未来针对肥胖症及其合并症的治疗研究提供了一个复杂但有前景的领域。
