College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Int J Mol Sci. 2024 Jul 2;25(13):7268. doi: 10.3390/ijms25137268.
Cell adhesion is a dynamic process that plays a fundamental role in cell proliferation, maintenance, differentiation, and migration. Basal cell adhesion molecule (BCAM), also known as Lutheran (Lu), belongs to the immunoglobulin superfamily of cell adhesion molecules. Lu/BCAM, which is widely expressed in red blood cells, endothelial cells, smooth muscle cells and epithelial cells across various tissues, playing a crucial role in many cellular processes, including cell adhesion, cell motility and cell migration. Moreover, Lu/BCAM, dysregulated in many diseases, such as blood diseases and various types of cancer, may act as a biomarker and target for the treatment of these diseases. This review explores the significance of Lu/BCAM in cell adhesion and its potential as a novel target for treating hematological diseases and tumors.
细胞黏附是一个动态过程，在细胞增殖、维持、分化和迁移中起着基础性作用。基底细胞黏附分子（BCAM），也称为路易斯（Lu），属于细胞黏附分子免疫球蛋白超家族。Lu/BCAM 广泛表达于各种组织中的红细胞、内皮细胞、平滑肌细胞和上皮细胞，在许多细胞过程中发挥关键作用，包括细胞黏附、细胞运动和细胞迁移。此外，Lu/BCAM 在许多疾病中失调，如血液疾病和各种类型的癌症，可能作为这些疾病治疗的生物标志物和靶标。本综述探讨了 Lu/BCAM 在细胞黏附中的意义及其作为治疗血液疾病和肿瘤的新靶标的潜力。
