Differential response patterns to MAO inhibitors and tricyclics.

The concept of atypical depression is reviewed and data comparing the clinical effects of monoamine oxidase inhibitors and tricyclic antidepressants are presented. Monoamine oxidase inhibitors are indicated for treatment of syndromes of panic and generalized anxiety with or without supervening atypical depression. The two classes of drugs have contrasting effects on adrenergic metabolism which may be related to the superior antianxiety and antipanic effects of monoamine oxidase inhibitors.