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SALL4和OCT3/4在小儿睾丸肿瘤中的诊断价值

Diagnostic Value of SALL4 and OCT3/4 in Pediatric Testicular Tumors.

作者信息

Bîcă Ovidiu, Ciongradi Carmen Iulia, Ivănuță Marius, Ianole Victor, Sârbu Ioan, Cojocaru Elena, Bîcă Delia Elena, Lozneanu Ludmila

机构信息

2nd Department of Surgery-Pediatric Surgery and Orthopedics, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.

Department of Urology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.

出版信息

Diagnostics (Basel). 2024 Jul 8;14(13):1454. doi: 10.3390/diagnostics14131454.

DOI:10.3390/diagnostics14131454
PMID:39001344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11241718/
Abstract

Testicular tumors (TTs) are rare in children, posing diagnostic and therapeutic challenges. This retrospective study evaluates the diagnostic and prognostic utility of SALL4 and OCT3/4 in pediatric TTs. We analyzed 18 cases of different types of TTs using immunohistochemistry (IHC) to assess SALL4 (Spalt-like transcription factor 4) and OCT3/4 (Octamer binding transcription factor 3/4) expression. SALL4 was positive in 83.3% of tumors, while OCT3/4 was positive in 38.9% of tumors, with a significantly higher prevalence in patients aged 12-18 years compared to those aged 0-11 years (). Mixed germinal cell tumors were significantly more frequently associated with OCT3/4 (), and a high immunostaining expression for SALL4 was observed primarily in yolk sac tumors and embryonal carcinoma. Our findings suggest that SALL4 and OCT3/4 immunostaining can aid in accurate diagnosis and treatment planning, and underscores the importance of OCT3/4 as a predictive factor in pediatric testicular tumors, highlighting its substantial correlation with tumor type and its impact on treatment response. These markers may guide personalized therapeutic strategies, potentially improving patient outcomes.

摘要

睾丸肿瘤（TTs）在儿童中较为罕见，带来了诊断和治疗方面的挑战。这项回顾性研究评估了SALL4和OCT3/4在儿童TTs中的诊断和预后效用。我们使用免疫组织化学（IHC）分析了18例不同类型的TTs，以评估SALL4（类Spalt转录因子4）和OCT3/4（八聚体结合转录因子3/4）的表达。83.3%的肿瘤中SALL4呈阳性，而38.9%的肿瘤中OCT3/4呈阳性，12至18岁患者中的患病率显著高于0至11岁患者（）。混合性生殖细胞肿瘤与OCT3/4的相关性显著更高（），并且主要在卵黄囊瘤和胚胎癌中观察到SALL4的高免疫染色表达。我们的研究结果表明，SALL4和OCT3/4免疫染色有助于准确诊断和治疗规划，并强调了OCT3/4作为儿童睾丸肿瘤预测因子的重要性，突出了其与肿瘤类型的显著相关性及其对治疗反应的影响。这些标志物可能指导个性化治疗策略， potentially improving patient outcomes. （原文此处表述有误，正确表述可能是“potentially improving patient outcomes”，翻译为“可能改善患者预后” ）这些标志物可能指导个性化治疗策略，可能改善患者预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c4d/11241718/ce09bb97f526/diagnostics-14-01454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c4d/11241718/3da343323bcb/diagnostics-14-01454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c4d/11241718/ce09bb97f526/diagnostics-14-01454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c4d/11241718/3da343323bcb/diagnostics-14-01454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c4d/11241718/ce09bb97f526/diagnostics-14-01454-g002.jpg

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Int J Mol Sci. 2024 Jun 19;25(12):6752. doi: 10.3390/ijms25126752.
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J Clin Lab Anal. 2023 May;37(9-10):e24927. doi: 10.1002/jcla.24927. Epub 2023 Jun 20.
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SALL4: An Intriguing Therapeutic Target in Cancer Treatment.SALL4：癌症治疗中一个引人关注的治疗靶点。
Cells. 2022 Aug 20;11(16):2601. doi: 10.3390/cells11162601.
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SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance.SALL4 在癌症中的致癌功能：机制和治疗相关性。
Int J Mol Sci. 2022 Feb 12;23(4):2053. doi: 10.3390/ijms23042053.
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The core four - A panel of immunohistochemistry markers to diagnose and subtype testicular germ cell tumors.核心四联——用于诊断和对睾丸生殖细胞肿瘤进行亚型分类的一组免疫组织化学标志物。
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Fertility of Cryptorchid Testis-An Unsolved Mistery.隐睾睾丸的生育能力——未解之谜。
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