Zürcher Sven, Martignoni Zora, Hunger Robert E, Benzaquen Michael, Seyed Jafari S Morteza
Department of Dermatology, Inselspital, Bern University Hospital, 3010 Bern, Switzerland.
Cancers (Basel). 2024 Jun 28;16(13):2394. doi: 10.3390/cancers16132394.
The first-line treatment of the localized form of cutaneous squamous cell carcinoma (cSCC) remains surgical excision. Either conventional excision (CE) with margins or Mohs micrographic surgery (MMS) may be preferred, depending on the risk factors of cSCC, the characteristics of the tumor, and the available technical facilities.
This article presents a systematic review of the current literature spanning from 1974 to 2023, comparing outcomes of cSCC treated with MMS versus cSCC treated with conventional excision.
Out of the 6821 records identified through the database search, a total of 156 studies were screened, of which 10 were included in the review. The majority of the included studies showed that treatment of cSCC with MMS consistently exhibits a significantly lower risk of recurrence compared to treatment with CE. In addition, MMS is emerging as the preferred technique for the resection of cSCC located in aesthetically or functionally challenging anatomical areas.
The studies generally demonstrate that MMS is a safer and more effective treatment of cSCC than CE. Nevertheless, outcomes such as recurrence rates and cost-effectiveness should be assessed more precisely, in order to allow for a more tailored approach in determining the appropriate indication for the use of MMS.
局限性皮肤鳞状细胞癌（cSCC）的一线治疗仍然是手术切除。根据cSCC的危险因素、肿瘤特征和可用技术设备，可优先选择带切缘的传统切除术（CE）或莫氏显微外科手术（MMS）。
本文对1974年至2023年的当前文献进行了系统综述，比较了MMS治疗cSCC与传统切除术治疗cSCC的结果。
通过数据库检索确定的6821条记录中，共筛选了156项研究，其中10项纳入综述。大多数纳入研究表明，与CE治疗相比，MMS治疗cSCC的复发风险始终显著更低。此外，MMS正成为切除位于美学或功能上具有挑战性的解剖区域的cSCC的首选技术。
研究总体表明，与CE相比，MMS是一种更安全、更有效的cSCC治疗方法。然而，应更精确地评估复发率和成本效益等结果，以便在确定使用MMS的合适适应症时采用更具针对性的方法。
