Moscow Regional Research and Clinical Institute (MONIKI), Moscow, Russia.
Nasonova Research Institute of Rheumatology, Moscow, Russia.
Dokl Biochem Biophys. 2024 Aug;517(1):269-276. doi: 10.1134/S1607672924700972. Epub 2024 Jul 13.
Gout is associated with increased risk of cardiovascular disease (CVD) morbidity and mortality. Therefore, an association between coronary heart disease (CHD) and gout deserves careful examination.
. The aim of this study was to determine the prevalence of CHD and factors associated with CHD in patients (pts) with gout.
. The study involved 286 male patients with gout, age 51.2 [42.8; 59.4] years (ys), disease duration 6.2 [3.8; 12.1] ys. All patients underwent standard clinical examination screening traditional risk factors (TRFs) of CVDs. We estimated the adjusted odds ratio (OR) and 95% confidence interval (95% CI).
. CHD was found in 111 out of the 286 pts (38.8%), MI had a history in 29.7%. Compared to individuals with CHD, participants without CHD were older (56.7[52.1; 61.1] vs 46.2[40.6; 53.4] ys), had longer duration of gout (9.3[4.7; 15.1] vs 5.6[3.3; 9.7] ys) (for all p < 0.05). Abdominal obesity (OR, 3.6; 95% CI, 1.2-10.9), family history of CHD (OR, 2.2; 95% CI, 1.3-3.7), disease duration of gout more 10 ys (OR, 2.8; 95% CI, 1.6-4.7), age of gout onset < 35 ys (OR, 5.5; 95% CI, 2.6-11.7), intraosseous tophi (OR, 3.03; 95% CI, 1.8-5.01), nephrolithiasis (OR, 1.7; 95% CI, 1.04-3.04), renal failure (OR, 5.6; 95% CI, 2.7-11.4), serum total cholesterol (TC), (OR, 1.6; 95% CI, 1.0-2.8), serum creatinine (OR, 2.5; 95% CI, 1.2-5.1), increased the risk for CHD in patients with a gout.
. The prevalence of CHD was 38.8% among individuals with gout (one-third of patients had a history of MI 29.7%). Our study showed that both TRFs of CVD and the severity of gout and a history of renal failure contribute to the development of CHD in patients with gout.
本研究旨在确定痛风患者中冠心病（CHD）的患病率和相关因素。
本研究纳入了 286 名年龄 51.2 [42.8；59.4] 岁的男性痛风患者（ys），疾病持续时间为 6.2 [3.8；12.1] ys。所有患者均接受了标准临床检查，筛查心血管疾病（CVDs）的传统危险因素（TRFs）。我们估计了调整后的优势比（OR）和 95%置信区间（95%CI）。
286 例患者中，111 例（38.8%）患有 CHD，29.7%有心肌梗死病史。与无 CHD 的患者相比，有 CHD 的患者年龄更大（56.7[52.1；61.1] vs 46.2[40.6；53.4] ys），痛风持续时间更长（9.3[4.7；15.1] vs 5.6[3.3；9.7] ys）（均<0.05）。腹型肥胖（OR，3.6；95%CI，1.2-10.9）、CHD 家族史（OR，2.2；95%CI，1.3-3.7）、痛风病程>10 ys（OR，2.8；95%CI，1.6-4.7）、痛风发病年龄<35 ys（OR，5.5；95%CI，2.6-11.7）、骨内痛风石（OR，3.03；95%CI，1.8-5.01）、肾结石（OR，1.7；95%CI，1.04-3.04）、肾功能衰竭（OR，5.6；95%CI，2.7-11.4）、血清总胆固醇（TC）（OR，1.6；95%CI，1.0-2.8）、血清肌酐（OR，2.5；95%CI，1.2-5.1），增加了痛风患者发生 CHD 的风险。
痛风患者中 CHD 的患病率为 38.8%（三分之一的患者有心肌梗死病史 29.7%）。本研究表明，心血管疾病的 TRFs 以及痛风的严重程度和肾功能衰竭病史均与痛风患者 CHD 的发生有关。
