State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou 310024, China.
J Colloid Interface Sci. 2024 Dec;675:857-869. doi: 10.1016/j.jcis.2024.07.038. Epub 2024 Jul 6.
Portal vein tumor thrombus (PVTT) formed by cancer cell invasion is a major cause of high mortality in hepatocellular carcinoma (HCC), and the formation of thrombus will be accelerated by bacterial colonization on the surface of the implant after surgery. In this work, Polypyrrole-coated arsenic-loaded layered double hydroxide films were in situ constructed on the nickel-titanium alloy for the efficient killing of tumour cells by thermo-therapeutic synergistic chemotherapy. The good near-infrared photothermal conversion ability of polypyrrole enables the sample surface temperature to be raised to about 51 °C at a low photothermal power (0.5 w/cm), while the elevated temperature could further accelerate the release of drug arsenic. In addition, when NIR light is not applied, the polypyrrole coating also cleverly acts as a "barrier layer" to reduce the natural release of arsenic in normal tissues to avoid toxicity issues. In vivo and in vitro experiments have demonstrated that the platform exhibits excellent antitumor and antibacterial abilities. In contrast to the systemic toxicity issues associated with systemic circulation of nanotherapeutic drugs, this in situ functional film is expected to be used in localised interventions for precise drug delivery, and is also more suitable for surgical treatment scenarios in PVTT surgeries.
门静脉癌栓（PVTT）是由癌细胞侵袭形成的，是肝细胞癌（HCC）高死亡率的主要原因，手术后细菌在植入物表面定殖会加速血栓的形成。在这项工作中，在镍钛合金上原位构建了负载砷的聚吡咯包覆的层状双氢氧化物薄膜，用于通过热疗协同化学疗法有效杀死肿瘤细胞。聚吡咯具有良好的近红外光热转换能力，使样品表面温度在低光热功率（0.5 w/cm）下升高到约 51°C，而升高的温度可以进一步加速药物砷的释放。此外，当不应用近红外光时，聚吡咯涂层还巧妙地充当“阻挡层”，以减少正常组织中砷的自然释放，避免毒性问题。体内和体外实验表明，该平台具有优异的抗肿瘤和抗菌能力。与纳米治疗药物全身循环相关的全身毒性问题相比，这种原位功能薄膜有望用于局部干预的精确药物输送，并且更适合 PVTT 手术中的外科治疗方案。
