Graduate Program in Nutrition, Center for Health Sciences, Federal University of Pernambuco, Recife-Pernambuco, Brazil; Studies in Nutrition and Phenotypic Plasticity Unit, Center for Health Sciences, Federal University of Pernambuco, Recife-Pernambuco, Brazil.
Graduate Program in Nutrition, Center for Health Sciences, Federal University of Pernambuco, Recife-Pernambuco, Brazil; Studies in Nutrition and Phenotypic Plasticity Unit, Center for Health Sciences, Federal University of Pernambuco, Recife-Pernambuco, Brazil; Graduate Program in Neuropsychiatry and Behavioral Sciences, Center for Medical Sciences, Federal University of Pernambuco, Recife-Pernambuco, Brazil.
Nutr Res. 2024 Aug;128:24-37. doi: 10.1016/j.nutres.2024.06.005. Epub 2024 Jun 17.
Chronic low-grade inflammation is a common feature of obesity and plays a crucial role in the progression of its complications. Vitamin D (VitD) plays an important role in modulating the immune response and regulating inflammation. Thus, this systematic review and meta-analysis aimed to evaluate the effects of isolated VitD supplementation on main inflammatory markers in overweight and obese individuals with no comorbidities and with VitD deficiency. We hypothesized that the increase in serum VitD concentrations after supplementation would significantly reduce the concentrations of inflammatory markers. The search was conducted in Medline/PubMed, SCOPUS, EMBASE, and Web of Science. Eleven randomized placebo-controlled studies were included in the final analysis, with a total of 504 participants and daily (1000-7000 international units) or bolus (100,000-200,000 international units) doses of VitD lasting from 2 to 26 weeks. The VitD supplementation did not influence C-reactive protein (mean difference [MD]: 0.01; 95% confidence interval [CI] -0.37, 0.39; P = .97), interleukin-6 (MD: -0.34; 95% CI -1.09, 0.42; P = .38), and tumor necrosis factor concentrations (MD: -0.02; 95% CI -0.23, 0.19; P = .85). In the analysis considering the studies with a significant increase in serum VitD concentrations, VitD supplementation also did not influence C-reactive protein (MD: -0.17; 95% CI -0.88, 0.54; P = .64), interleukin-6 (MD: -0.47; 95% CI -1.31, 0.37; P = .27), and tumor necrosis factor concentrations (MD: 0.01; 95% CI -1.34, 1.37; P = .98). This meta-analysis suggests that VitD supplementation does not significantly alter inflammatory markers in overweight and obese individuals.
慢性低度炎症是肥胖的一个常见特征，在其并发症的进展中起着关键作用。维生素 D（VitD）在调节免疫反应和调节炎症方面起着重要作用。因此，本系统评价和荟萃分析旨在评估单独补充 VitD 对无合并症和 VitD 缺乏的超重和肥胖个体主要炎症标志物的影响。我们假设补充后血清 VitD 浓度的增加将显著降低炎症标志物的浓度。检索范围包括 Medline/PubMed、SCOPUS、EMBASE 和 Web of Science。最终分析纳入了 11 项随机安慰剂对照研究，共有 504 名参与者，VitD 每日（1000-7000 国际单位）或大剂量（100000-200000 国际单位）补充，持续 2-26 周。VitD 补充对 C 反应蛋白（平均差 [MD]：0.01；95%置信区间 [CI] -0.37，0.39；P =.97）、白细胞介素-6（MD：-0.34；95% CI -1.09，0.42；P =.38）和肿瘤坏死因子浓度（MD：-0.02；95% CI -0.23，0.19；P =.85）没有影响。在考虑血清 VitD 浓度显著升高的研究的分析中，VitD 补充也没有影响 C 反应蛋白（MD：-0.17；95% CI -0.88，0.54；P =.64）、白细胞介素-6（MD：-0.47；95% CI -1.31，0.37；P =.27）和肿瘤坏死因子浓度（MD：0.01；95% CI -1.34，1.37；P =.98）。本荟萃分析表明，VitD 补充对超重和肥胖个体的炎症标志物没有显著影响。
