Mattioli Anna Vittoria, Coppi Francesca, Severino Paolo, Penna Claudia, Pagliaro Pasquale, Dei Cas Alessandra, Bucciarelli Valentina, Madonna Rosalinda, Tarperi Cantor, Schena Federico, Cetrullo Silvia, Angelone Tommaso, Rocca Carmine, Parenti Astrid, Palazzuoli Alberto, Margonato Alberto, Paolillo Stefania, Perrone Filardi Pasquale, Barillà Francesco, Lombardi Carlo, Pinti Marcello, Molinari Claudio, Cevese Antonio, Novo Giuseppina, Pizzi Carmine, Porto Italo, Poggesi Corrado, Gallina Sabina, Ambrosio Giuseppe, Fedele Francesco
Istituto Nazionale per le Ricerche Cardiovascolari, 40126 Bologna, Italy.
Nutrients. 2024 Dec 30;17(1):115. doi: 10.3390/nu17010115.
Vitamin D is increasingly recognized for its role in cardiovascular health beyond its well-established effects on bone metabolism. This review synthesizes findings from observational studies, interventional trials, and meta-analyses to clarify the mechanisms through which vitamin D impacts cardiovascular health, including its influence on vascular function, inflammation, and metabolic pathways. Additionally, this review emphasizes the importance of a personalized approach to vitamin D supplementation, integrating individual cardiovascular risk profiles, baseline vitamin D levels, and comorbid conditions, such as hypertension and diabetes. While current evidence supports the association between low vitamin D levels and increased cardiovascular mortality, this work contributes novel insights by proposing tailored strategies for supplementation, particularly for high-risk subgroups. Practical recommendations for implementing these strategies in clinical practice are also discussed, providing a framework for optimizing cardiovascular outcomes through individualized vitamin D management.
维生素D在心血管健康方面的作用日益受到认可，其对骨骼代谢的影响早已明确。本综述综合了观察性研究、干预性试验和荟萃分析的结果，以阐明维生素D影响心血管健康的机制，包括其对血管功能、炎症和代谢途径的影响。此外，本综述强调了个性化补充维生素D方法的重要性，该方法综合考虑个体心血管风险状况、维生素D基线水平以及合并症，如高血压和糖尿病。虽然目前的证据支持低维生素D水平与心血管死亡率增加之间的关联，但本研究通过提出针对性的补充策略，特别是针对高危亚组，提供了新的见解。还讨论了在临床实践中实施这些策略的实用建议，为通过个体化维生素D管理优化心血管结局提供了一个框架。
