Forrester Ryan, Dutech Guy, Akin Andrew, Fassbender Michael E, Mastren Tara
Nuclear Engineering Program, University of Utah, 110 Central Campus Dr, Salt Lake City, UT 84112, USA.
Chemistry Division, Los Alamos National Laboratory, PO Box 1663, Los Alamos, NM 87545, USA.
Nucl Med Biol. 2024 Sep-Oct;136-137:108941. doi: 10.1016/j.nucmedbio.2024.108941. Epub 2024 Jul 9.
Bismuth-213 is a radionuclide of interest for targeted alpha therapy and is supplied via a radiochemical generator system through the decay of Ac. Radionuclide generators employ longer lived "parent" radionuclides to routinely supply shorter-lived "daughter" radionuclides. The traditional Ac/Bi radiochemical generator relies on an organic cation exchange resin where Ac binds to the resin and Bi is routinely eluted. These resins degrade when they absorb large doses of ionizing radiation (>1 × 10 Gy/mg), which has been observed when the loading activity of Ac exceeds 2.59*10 Bq (70 mCi). Herein we report the development of an electrochemical generator for the supply of Bi that has the potential to overcome this limitation. Bismuth-213 spontaneously electrodeposits onto nickel foils in 0.1 M hydrochloric acid at 70 °C. Using this method, we were able to plate an average of 73 ± 4 % of the Bi in solution and obtain a final Bi recovery of 65 ± 8 % in 0.1 M citrate pH 4.5 via reverse electrolysis using titanium as the cathode. The recovered Bi had an average radiochemical purity of >99.8 % and was successfully used to radiolabel DOTATATE with an average radiochemical yield of 85.1 % (not optimized).
铋 - 213是一种用于靶向α治疗的放射性核素，通过锕的衰变经放射化学发生器系统供应。放射性核素发生器利用寿命较长的“母体”放射性核素来常规供应寿命较短的“子体”放射性核素。传统的锕/铋放射化学发生器依赖于有机阳离子交换树脂，其中锕与树脂结合，铋则常规洗脱。当这些树脂吸收大剂量电离辐射（>1×10 Gy/mg）时会发生降解，当锕的装载活度超过2.59×10 Bq（70 mCi）时就会观察到这种情况。在此，我们报告了一种用于供应铋的电化学发生器的开发，它有可能克服这一限制。铋 - 213在70°C的0.1 M盐酸中自发电沉积到镍箔上。使用这种方法，我们能够在溶液中平均电镀出73±4%的铋，并通过以钛为阴极的反向电解在0.1 M pH 4.5的柠檬酸盐中最终获得65±8% 的铋回收率。回收的铋平均放射化学纯度>99.8%，并成功用于标记DOTATATE，平均放射化学产率为85.1%（未优化）。
