Wang Xiaoqin, Xia Yi, Yan Rui, Sun Hao, Huang Yinghong, Xia Qiudong, Sheng Junling, You Wei, Hua Lingling, Tang Hao, Yao Zhijian, Lu Qing
The Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, China.
Nanjing Brain Hospital, Medical School of Nanjing University, 22 Hankou Road, Nanjing, 210093, China.
Eur Arch Psychiatry Clin Neurosci. 2024 Apr 1. doi: 10.1007/s00406-024-01765-4.
Previous studies about anhedonia symptoms in bipolar depression (BD) ignored the unique role of gender on brain function. This study aims to explore the regional brain neuroimaging features of BD with anhedonia and the sex differences in these patients. The resting-fMRI by applying fractional amplitude of low-frequency fluctuation (fALFF) method was estimated in 263 patients with BD (174 high anhedonia [HA], 89 low anhedonia [LA]) and 213 healthy controls. The effects of two different factors in patients with BD were analyzed using a 3 (group: HA, LA, HC) × 2 (sex: male, female) ANOVA. The fALFF values were higher in the HA group than in the LA group in the right medial cingulate gyrus and supplementary motor area. For the sex-by-group interaction, the fALFF values of the right hippocampus, left medial occipital gyrus, right insula, and bilateral medial cingulate gyrus were significantly higher in HA males than in LA males but not females. These results suggested that the pattern of high activation could be a marker of anhedonia symptoms in BD males, and the sex differences should be considered in future studies of BD with anhedonia symptoms.
先前关于双相抑郁症（BD）中快感缺乏症状的研究忽略了性别对大脑功能的独特作用。本研究旨在探讨伴有快感缺乏的双相抑郁症患者的大脑区域神经影像学特征以及这些患者中的性别差异。对263例双相抑郁症患者（174例高快感缺乏[HA]，89例低快感缺乏[LA]）和213名健康对照者进行了基于低频振幅分数（fALFF）方法的静息态功能磁共振成像。使用3（组：HA、LA、HC）×2（性别：男性、女性）方差分析来分析双相抑郁症患者中两个不同因素的影响。在右侧扣带回中部和辅助运动区，HA组的fALFF值高于LA组。对于性别-组交互作用，HA男性的右侧海马、左侧枕叶内侧回、右侧岛叶和双侧扣带回中部的fALFF值显著高于LA男性，而女性则无此差异。这些结果表明，高激活模式可能是双相抑郁症男性快感缺乏症状的一个标志，在未来对伴有快感缺乏症状的双相抑郁症研究中应考虑性别差异。
