生活方式因素对避孕埋植剂使用者血清依托孕烯浓度的影响。
The influence of lifestyle factors on serum etonogestrel concentrations among contraceptive implant users.
机构信息
University of Colorado Anschutz Medical Campus, Department of Obstetrics and Gynecology, Division of Family Planning, Aurora, CO, USA.
University of Colorado Anschutz Medical Campus, Department of Obstetrics and Gynecology, Division of Family Planning, Aurora, CO, USA.
出版信息
Contraception. 2024 Dec;140:110539. doi: 10.1016/j.contraception.2024.110539. Epub 2024 Jul 11.
OBJECTIVE
To evaluate how diet, exercise, and substance use influence serum etonogestrel concentrations among contraceptive implant users.
STUDY DESIGN
We conducted a cross-sectional analysis of healthy, reproductive-age etonogestrel implant users. We assessed participants' current diet, exercise, and substance (alcohol, tobacco, marijuana) use habits while simultaneously measuring serum etonogestrel concentrations. We used linear modeling to test for associations between survey responses and etonogestrel concentrations.
RESULTS
Among 115 participants, exercise habits and substance use had no significant associations with etonogestrel concentrations, while increased caloric intake demonstrated inconsistent associations.
CONCLUSION
The lifestyle factors of diet, exercise, and substance use do not influence steady-state pharmacokinetics among contraceptive implant users.
CLINICAL TRIAL REGISTRATION
Clinicaltrials.gov, NCT03092037.
目的
评估饮食、运动和物质使用如何影响避孕植入物使用者的血清依托孕烯浓度。
研究设计
我们对健康、育龄期依托孕烯植入物使用者进行了横断面分析。我们评估了参与者当前的饮食、运动和物质（酒精、烟草、大麻）使用习惯，同时测量了血清依托孕烯浓度。我们使用线性模型来测试调查回复与依托孕烯浓度之间的关联。
结果
在 115 名参与者中，运动习惯和物质使用与依托孕烯浓度没有显著关联，而热量摄入的增加则表现出不一致的关联。
结论
饮食、运动和物质使用等生活方式因素不会影响避孕植入物使用者的稳态药代动力学。
临床试验注册
Clinicaltrials.gov，NCT03092037。
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