一项关于生活方式因素与避孕埋植剂使用者血清依托孕烯浓度相关性的探索性研究。
An exploratory study on the association of lifestyle factors with serum etonogestrel concentrations among contraceptive implant users.
机构信息
Department of Obstetrics and Gynecology, Division of Family Planning, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
出版信息
Eur J Contracept Reprod Health Care. 2021 Aug;26(4):323-325. doi: 10.1080/13625187.2021.1887475. Epub 2021 Feb 17.
PURPOSE
To explore how diet and exercise habits associate with serum etonogestrel concentrations among contraceptive implant users.
MATERIALS AND METHODS
We conducted a secondary analysis of healthy, reproductive-age women using etonogestrel implants. This study was registered on ClinicalTrials.gov, NCT03092037. We assessed diet and exercise habits with two validated surveys: Healthy Eating Vital Signs and the Stanford Brief Activity Survey. Participants previously had their serum etonogestrel concentrations measured using a validated liquid-chromatography mass-spectrometry assay. We then used linear modelling to test for associations between survey responses and serum etonogestrel concentrations.
RESULTS
Among 129 participants, diet and exercise habits had no significant associations with serum etonogestrel concentrations ( = 0.22-0.72), with inconsistent effects found for increased caloric intake and sedentary lifestyle.
CONCLUSION
This exploratory study found no significant effect of diet or exercise habits on steady-state pharmacokinetics among contraceptive implant users.
CLINICAL TRIAL REGISTRATION
Clinicaltrials.gov: NCT03092037.
目的
探讨避孕植入物使用者的饮食和运动习惯与血清依托孕烯浓度之间的关系。
材料与方法
我们对使用依托孕烯植入物的健康育龄妇女进行了二次分析。本研究在 ClinicalTrials.gov 上注册，编号为 NCT03092037。我们使用两项经过验证的调查评估了饮食和运动习惯：健康饮食生命体征和斯坦福简短活动调查。参与者之前使用经过验证的液相色谱-质谱法测量了他们的血清依托孕烯浓度。然后，我们使用线性模型来测试调查结果与血清依托孕烯浓度之间的关联。
结果
在 129 名参与者中，饮食和运动习惯与血清依托孕烯浓度无显著相关性（ = 0.22-0.72），对于增加的热量摄入和久坐不动的生活方式，发现的影响不一致。
结论
这项探索性研究发现，饮食或运动习惯对避孕植入物使用者的稳态药代动力学无显著影响。
临床试验注册
Clinicaltrials.gov：NCT03092037。
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